Mouse protein coding diversity: What’s left to discover?

English version

Autoři: Jingtao Lilue ^aff001; Anu Shivalikanjli ^aff001; David J. Adams ^aff003; Thomas M. Keane ^aff001
Působiště autorů: European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom ^aff001; Instituto Gulbenkian de Ciência, Oeiras, Lisbon, Portugal ^aff002; Wellcome Sanger Institute, Hinxton, United Kingdom ^aff003; School of Life Sciences, University of Nottingham, Nottingham, United Kingdom ^aff004
Vyšlo v časopise: Mouse protein coding diversity: What’s left to discover?. PLoS Genet 15(11): e32767. doi:10.1371/journal.pgen.1008446
Kategorie: Review
doi: https://doi.org/10.1371/journal.pgen.1008446

Souhrn

For over a century, mice have been used to model human disease, leading to many fundamental discoveries about mammalian biology and the development of new therapies. Mouse genetics research has been further catalysed by a plethora of genomic resources developed in the last 20 years, including the genome sequence of C57BL/6J and more recently the first draft reference genomes for 16 additional laboratory strains. Collectively, the comparison of these genomes highlights the extreme diversity that exists at loci associated with the immune system, pathogen response, and key sensory functions, which form the foundation for dissecting phenotypic traits in vivo. We review the current status of the mouse genome across the diversity of the mouse lineage and discuss the value of mice to understanding human disease.

Klíčová slova:

Comparative genomics – Haplotypes – Human genomics – Inbred strains – Inbreeding – Mammalian genomics – Mice – Mouse models

Zdroje

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