Intestinal microbiome in patients with chronic pancreatitis

Česká verze

Authors: David Solil ¹; Petr Dítě ^1,2 ; Marie Přecechtělová ¹; Magdalena Uvírová ³ ; Jiří Dolina ^1,4 ; Arnošt Martínek ^2,5
Authors place of work: Interní gastroenterologická klinika LF MU a FN Brno ¹; Lékařská fakulta OU, Ostrava ²; EUC Laboratoře CGB a. s., Ostrava ³; Lékařská fakulta MU, Brno 5 Interní kardiologická klinika, FN Ostrava ⁴
Published in the journal: Gastroent Hepatol 2024; 78(3): 242-246
Category: Přehledová práce
doi: https://doi.org/10.48095/ccgh2024242

Summary

We refer to the microflora inhabiting the intestine as a whole as the intestinal microbiota, and their genomes collectively as the microbiome. Dysbiosis is a violation of the balance between the intestinal microbiota, the immune system and the epithelial intestinal barrier. Dysbiosis is associated not only with a number of gastrointestinal diseases, including inflammatory and cancerous diseases of the pancreas. We do not know the answer as to whether dysbiosis is a causal factor in the development of chronic pancreatitis, but it is a fact that, for example, the severity of the disease or changes in exocrine or endocrine pancreatic function are related to the intestinal microbiota. Pancreatic enzymes, especially pancreatic elastase, are significantly involved in the modulation of intestinal microflora. Specific changes in the composition of the intestinal microbiome in people with an autoimmune form of chronic pancreatitis could also become early diagnostic markers of the disease. It is evident that systematic research is more than desirable in this area of pancreatology.

Keywords:

intestinal microbiome – chronic pancreatitis – autoimmune pancreatitis – diabetes mellitus – exocrine pancreatic insufficiency – corticoids

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ORCID autorů

P. Dítě 0000-0002-0086-5421,

M. Uvírová 0000-0002-2783-5724,

J. Dolina 0000-0002-9061-5273,

A. Martínek 0000-0001-7597-3235.

Doručeno/Submitted: 19. 2. 2024

Přijato/Accepted: 19. 4. 2024

prof. MUDr. Petr Dítě, DrSc.

Interní gastroenterologická klinika

LF MU a FN Brno

Jihlavská 340/20

625 00 Brno