Hodnocení prodloužení QT u dětí s cirhózou a její souvislost se závažností nemocí jater

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Autoři: N. Mehdizadegan ¹ ; S. M. Dehghani ¹ ; S. Zare ¹ ; I. Shahramian ¹ ; M. Tahani ² ; M. Ataollahi ¹
Působiště autorů: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ¹; Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran ²
Vyšlo v časopise: Gastroent Hepatol 2024; 78(3): 259-265
Kategorie: Původní práce
doi: https://doi.org/10.48095/ccgh2024259

Souhrn

Úvod: Prodloužení QT intervalu na elektrokardiogramu (EKG) je pozorováno u více než 60 % dospělých s pokročilou cirhózou. Podle pečlivého výzkumu měli lidé s cirhózou, kteří mají prodloužené QT intervaly, horší míru přežití, závažnější příznaky onemocnění a rychlejší vývoj jejich stavu. Vzhledem k důležitosti predikce komplikací jaterní cirhózy u dětí a omezenému počtu studií týkajících se vztahu mezi prodlouženým QT a závažností jaterního onemocnění u dětí v této studii bylo zkoumáno prodloužené QT u dětí s jaterní cirhózou a její vztah k závažnosti jaterního onemocnění. Metody: V této studii byly děti do 18 let s jaterní cirhózou hodnoceny v seznamu transplantací jater odeslaných do nemocnice Abu Ali Sina Organ Transplantation Hospital v Shirazu v letech 2019 až 2021. QT bylo vypočteno na základě 12svodové EKG z operace transplantace jater. Výsledky: V této studii bylo hodnoceno 130 pacientů s jaterní cirhózou s průměrným věkem 7,05 ± 5,34. Průměrná délka QT segmentu byla hlášena jako 397 ± 31 milisekund. Pouze 4 (3 %) měli dlouhý QT segment u všech studovaných pacientů. Porovnání kritéria Meld/Peld a kritéria Child ve dvou skupinách s pravidelným QT a prodlouženým QT ukázalo, že průměr obou kritérií je významně delší ve skupině se standardním QT (p = 0,018; p = 0,038). Také prodloužené QT prokázalo významnou souvislost s příčinou jaterní cirhózy (p = 0,003). Závěr: Naše studie je jednou z prvních, která zkoumala vztah mezi QT a závažností cirhózy u dětí. Na základě výsledků této studie je prodloužený QT interval spojen se závažností onemocnění jater.

Klíčová slova:

játra – cirhóza – děti – dlouhé QT – fibróza

Zdroje

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ORCID authors

N. Mehdizadegan 0000-0001-6538-1391,

S. M. Dehghani 0000-0001-5930-0110,

S. Zare 0000-0002-5113-3781,

I. Shahramian 0000-0002-3760-7717,

M. Tahani 0000-0002-0213-9087,

M. Ataollahi 0000-0003-1876-5266.

Submitted/Doručeno: 19. 6. 2023

Accepted/Přijato: 23. 8. 2024

Assoc. Prof. Maryam Ataollahi, MD

Pediatrics Gastroenterology, Department of Pediatrics

School of Medicine Namazi Teaching Hospital