Serum levels of infliximab and antibodies to infliximab, clinical using
Authors:
L. Gombošová 1; M. Zakuciová 1; E. Barlová 2; L. Novotná 2; E. Veseliny 1
Authors place of work:
I. interná klinika, LF UPJŠ a UNLP Košice, 2Oddelenie laboratórnej medicíny, lekárska imunológia, UNLP Košice
1
Published in the journal:
Gastroent Hepatol 2012; 66(1): 32-36
Category:
IBD: přehledová práce
Summary
Timely diagnosing, precise treatment and the individual approach are needed for complex management of patients with inflammatory bowel diseases. The goal of the complex and individual approach is to achieve and maintain the remission and to minimize the complications. Tumor necrosis factor alpha (TNF-α) is the key cytokine of the chronic bowel inflammation. Infliximab is the longest used biologic compound. Infliximab reduces TNF-α levels, regulates inflammation and induces remission. Monitoring of the infliximab levels and antibodies to infliximab can contribute to optimalization of the biological therapy and tailoring to individual cases. Loss of response can be also caused by undetectable levels or positive antibodies to infiximab.
Key words:
infliximab – Crohn’s disease – ulcerative colitis – pharmacokinetics
Zdroje
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Štítky
Dětská gastroenterologie Gastroenterologie a hepatologie Chirurgie všeobecnáČlánek vyšel v časopise
Gastroenterologie a hepatologie
2012 Číslo 1
- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
- Horní limit denní dávky vitaminu D: Jaké množství je ještě bezpečné?
- Porovnání nízkoobjemového a vysokoobjemového roztoku k přípravě střeva před kolonoskopií u různých podskupin pacientů
- Neodolpasse je bezpečný přípravek v krátkodobé léčbě bolesti
Nejčtenější v tomto čísle
- Příprava střeva ke kolonoskopii
- Gastrokolická fistula
- Sérové hladiny infliximabu a protilátok proti infliximabu, prínos pre prax
- Význam vitamínu D pri nešpecifických črevných zápalových ochoreniach