Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons

English version

Autoři: Lewis M. Sherer ^aff001; Elizabeth Catudio Garrett ^aff001; Hannah R. Morgan ^aff002; Edmond D. Brewer ^aff002; Lucy A. Sirrs ^aff002; Harold K. Shearin ^aff003; Jessica L. Williams ^aff003; Brian D. McCabe ^aff004; R. Steven Stowers ^aff003; Sarah J. Certel ^aff001
Působiště autorů: Cellular, Molecular and Microbial Biology Graduate Program, University of Montana, Missoula, Montana, United States of America ^aff001; Division of Biological Sciences, Center for Structural and Functional Neuroscience, University of Montana, Missoula, Montana, United States of America ^aff002; Cell Biology and Neuroscience Department, Montana State University, Bozeman, Montana, United States of America ^aff003; Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland ^aff004
Vyšlo v časopise: Octopamine neuron dependent aggression requires dVGLUT from dual-transmitting neurons. PLoS Genet 16(2): e32767. doi:10.1371/journal.pgen.1008609
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pgen.1008609

Souhrn

Neuromodulators such as monoamines are often expressed in neurons that also release at least one fast-acting neurotransmitter. The release of a combination of transmitters provides both “classical” and “modulatory” signals that could produce diverse and/or complementary effects in associated circuits. Here, we establish that the majority of Drosophila octopamine (OA) neurons are also glutamatergic and identify the individual contributions of each neurotransmitter on sex-specific behaviors. Males without OA display low levels of aggression and high levels of inter-male courtship. Males deficient for dVGLUT solely in OA-glutamate neurons (OGNs) also exhibit a reduction in aggression, but without a concurrent increase in inter-male courtship. Within OGNs, a portion of VMAT and dVGLUT puncta differ in localization suggesting spatial differences in OA signaling. Our findings establish a previously undetermined role for dVGLUT in OA neurons and suggests that glutamate uncouples aggression from OA-dependent courtship-related behavior. These results indicate that dual neurotransmission can increase the efficacy of individual neurotransmitters while maintaining unique functions within a multi-functional social behavior neuronal network.

Klíčová slova:

Aggression – Behavior – Drosophila melanogaster – Glutamate – Motor neurons – Neurons – Synaptic vesicles – Neurotransmitter receptor signaling

Zdroje

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