p63 – důležitý hráč ve vývoji epidermálních struktur a nádorových onemocnění

English version

Autoři: P. Orzol; M. Nekulová; B. Vojtesek; J. Holcakova
Působiště autorů: Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Vyšlo v časopise: Klin Onkol 2012; 25(Supplementum 2): 11-15

Práce byla podpořena grantem GA MZ ČR P301/10/P431 a Evropským fondem pro regionální rozvoj a státním rozpočtem České republiky (OP VaVpI – RECAMO, CZ.1.05/2.1.00/03.0101).

Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.

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Obdrženo: 28. 9. 2012
Přijato: 24. 10. 2012

Souhrn

Protein p63 je transkripční faktor, který má významnou funkci ve vývoji a diferenciaci epidermálních struktur a v průběhu tumorigeneze. Je členem rodiny nádorového supresoru p53 a vyskytuje se minimálně v počtu šesti izoforem, které mají během vývoje epidermis a při vzniku a progresi nádorů opačné funkce. Protein p63 ovlivňuje proliferaci a diferenciaci epidermálních buněk v průběhu ontogeneze: vrozené mutace v genu TP63 vedou k různým vývojovým deformacím a odstranění tohoto genu u myší má za následek ztrátu epidermis. Protein p63 také ovlivňuje buněčnou adhezi prostřednictvím regulace desmozomů. Ztráta kontroly proliferace buněk a mezibuněčné adheze je přitom důležitou událostí při vývoji nádorů a vysoká hladina p63 podporuje růst nádorů a brání apoptóze nádorových buněk. Tento přehledový článek stručně shrnuje úlohy proteinu p63 ve vývoji epitelů, buněčné proliferaci, adhezi a migraci a poodhaluje jeho význam při vzniku nádorových onemocnění a tvorbě metastáz.

Klíčová slova:
p63 – epidermální vývoj – buněčná proliferace – buněčná adheze – vývoj nádorového onemocnění – epidermis

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