Kontrola kvality proteinů a kancerogeneze
Autoři:
F. Trcka; B. Vojtesek; P. Müller
Působiště autorů:
Regional Centre for Applied and Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
Vyšlo v časopise:
Klin Onkol 2012; 25(Supplementum 2): 38-44
Práce byla podpořena granty IGA MZ ČR NT/13794-4/2012, GAČR P206/12/G151 a Evropským fondem pro regionální rozvoj a státním rozpočtem České republiky (OP VaVpI – RECAMO, CZ.1.05/2.1.00/03.0101).
Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.
Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do bi omedicínských časopisů.
Obdrženo: 2. 10. 2012
Přijato: 1. 11. 2012
Souhrn
V průběhu své syntézy i po jejím dokončení jsou buněčné proteiny vystavovány vnějším i vnitřním faktorům způsobujícím jejich poškození. Nefunkční či nesprávně složené proteiny představují přímé fyziologické riziko pro vysoce komplexní buněčné prostředí a musejí být efektivně odstraňovány. U eukaryotních buněk se vyvinulo několik mechanizmů kontroly proteinové kvality zajišťujících proteinovou homeostázu. Významnou roli hrají tyto mechanizmy v nádorových buňkách, u nichž genetická nestabilita spolu s nepříznivým prostředím nádorové tkáně vede ke zvýšené produkci poškozených nebo deregulovaných proteinů. Kontrola kvality proteinů zahrnující rovněž degradaci nádorových supresorů a onkoproteinů tak představuje důležitý proces provázející vznik a vývoj nádoru. V tomto souhrnném článku se zaměřujeme na popis tří hlavních buněčných mechanizmů kontroly kvality proteinů se zvláštním ohledem na jejich úlohu v kancerogenezi.
Klíčová slova:
kontrola kvality proteinů – ubikvitinace – endoplasmatické retikulum – autofagie
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Štítky
Dětská onkologie Chirurgie všeobecná OnkologieČlánek vyšel v časopise
Klinická onkologie
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