Authors: P. Husa Authors‘ workplace: Klinika infekčních chorob Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Petr Husa, CSc. Published in: Vnitř Lék 2012; 58(7 a 8): 202-204 Category: 60th Birthday prof. MUDr. Miroslav Souček, CSc.
The 2011 has brought about a significant change in the treatment of chronic hepatitis C virus (HCV) infection. This change has been enabled by commercial availability of new antiviral agents for treatment of chronic HCV infection – telaprevir and boceprevir – in combination with pegylated interferon (PEG-IFN) α and ribavirin (RBV). The triple combination is significantly more effective than the PEG-IFN and RBV combination alone in antiviral treatment-naive patients as well as in patients in whom the traditional PEG-IFN and RBV combination did not provide permanent HCV infection elimination. In treatment-naive patients, the triple combination is approximately 2-fold more effective than the standard treatment with PEG-IFN and RBV and the effect of the triple combination is 3-fold higher when used in pre-treated patients instead of repeated PEG-IFN and RBV treatment.
Key words: chronic hepatitis C – boceprevir – telaprevir
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