Megakaryopoesis and platelet genesis

Czech version

Authors: M. Pecka
Authors‘ workplace: Oddělení klinické hematologie II. interní kliniky LF UK a FN a Katedra vnitřního lékařství LF UK Hradec Králové, přednosta prof. MUDr. Jaroslav Malý, CSc.
Published in: Vnitř Lék 2012; 58(7 a 8): 152-154
Category: 60th Birthday prof. MUDr. Miroslav Penka, CSc.

Overview

Similar to other haematopoietic cells, megakaryocytes originate from haematopoietic stem cells. Proliferation and maturation of the megacaryotic cell line is stimulated by a number of factors. This process is different in progenitor and precursor cells. Towards the end of their development, mature megakaryocytes are transferred and are localized near the bone marrow sinus wall. „Proplatelets“ are formed in cytoplasmic extensions of megakaryocytes and are subsequently separated from parental megacaryocyte and transformed into platelets in the circulation.

Key words:
thrombocytes – megakaryopoesis – thrombopoesis

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