High dose treatments and preparatory regimens prior to haematopoietic stem cell transplantation

Czech version

Authors: M. Tomíška; Z. Kořístek; M. Navrátil; J. Mayer
Authors‘ workplace: Interní hematologická a onkologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jiří Mayer, CSc.
Published in: Vnitř Lék 2012; 58(7 a 8): 175-180
Category: 60th Birthday prof. MUDr. Miroslav Penka, CSc.

Overview

High-dose chemotherapy can be defined as utilization of cytotoxic drug doses that produce bone marrow ablation. Transfusion of autologous graft serves as rescue from otherwise fatal myelotoxicity. Immune reaction of graft versus tumor that lowers relaps rates of malignant disease becomes an important contribution of allogeneic hematopoietic stem cell transplantation. New reduced intensity conditioning regimens with lower initial cytotoxicity rely on this immune effect with the potencial of additional elimination of remaining cancer cells. Decreased toxicity of these regimens enables treatment of patients with comorbidity and/or in higher age.

Key words:
high-dose chemotherapy – hematopoietic stem cell transplantation – conditioning regimen – nonmyeloablative conditioning

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