Fixed combinations in the treatment of hypertension

Czech version

Authors: J. Špinar ¹; J. Vítovec ²; L. Špinarová ²; M. Bendová ³
Authors‘ workplace: Interní kardiologická klinika Lékařské fakulty MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jindřich Špinar, CSc., FESC ¹; I. interní kardioangiologická klinika Lékařské fakulty MU a FN u sv. Anny – ICRC Brno, přednosta prof. MUDr. Jiří Vítovec, CSc., FESC ²; Nemocniční lékárna FN Brno, pracoviště Bohunice, vedoucí PharmDr. Tatiana Holubová ³
Published in: Vnitř Lék 2012; 58(7 a 8): 215-222
Category: 60th Birthday prof. MUDr. Miroslav Souček, CSc.

Overview

We present an overview of current opinions on combination therapy and the role of fixed combinations in the treatment of hypertension as per the ESH/ESC and CSH guidelines of 2007 and the revised European guidelines of 2009. A renin-angiotensin system blocker (ACE-I or sartan) combined with a calcium channel blocker is the most frequently recommended combination, followed by renin-angiotensin system blocker and a diuretic and a calcium channel blocker and a diuretic. A fixed combination of a calcium channel blocker and a beta-blocker has now been also recommended. Higher patient compliance and thus better control of hypertension is the main advantage of fixed combinations. We present an overview of fixed combinations registered in the Czech Republic until May 2012.

Key words:
hypertension – combination therapy – fixed combinations

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