Biomarker GDF-15 in cardiology

Česká verze

Authors: Štěpán Havránek; Josef Marek
Authors place of work: II. interní klinika – klinika kardiologie a angiologie 1. lékařské fakulty Univerzity Karlovy, a Všeobecné fakultní nemocnice v Praze
Published in the journal: Vnitř Lék 2021; 67(E-3): 11-14
Category: Přehledové články

Summary

GDF-15 (Growth differentiation factor 15) is a protein synthesised in some tissues including liver, kidney, heart, or lung. GDF-15 a stress-responsive cytokine. GDF-15 is emerging as a biomarker of cardiometabolic risk and disease burden. GDF-15 is linked to the incidence and prognosis of heart failure. In acute coronary syndromes GDF-15 identifies risk of complications including bleeding, reinfarction, development of heart failure or mortality. In patients with atrial fibrillation, GDF-15 is a potent marker of bleeding adverse events in anticoagulated patients and a predictor of overall mortality. Role of GDF-15 in cardiology is not definitively constituted.

Keywords:

GDF-15 – biomarker – heart failure – coronary artery disease – atrial fibrillation

Zdroje

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