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In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction


Autoři: Sandra Silva-Arrieta aff001;  Philip J. R. Goulder aff002;  Christian Brander aff001
Působiště autorů: IrsiCaixa AIDS Research Institute, Hospital Germans Trias i Pujol, Institute for Health Science Research Germans Trias i Pujol (IGTP), Badalona, Spain aff001;  Department of Paediatrics, University of Oxford, Oxford, United Kingdom aff002;  HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa aff003;  Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America aff004;  University of Vic–Central University of Catalonia, Catalonia, Vic, Spain aff005;  Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain aff006
Vyšlo v časopise: In silico veritas? Potential limitations for SARS-CoV-2 vaccine development based on T-cell epitope prediction. PLoS Pathog 16(6): e32767. doi:10.1371/journal.ppat.1008607
Kategorie: Opinion
doi: https://doi.org/10.1371/journal.ppat.1008607


Zdroje

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3. Nixon DF, Townsend AR, Elvin JG, Rizza CR, Gallwey J, McMichael AJ. HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides Nature. 1988;336(6198):484–7.

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5. Llano A, Cedeño S, Silva-Arrieta S, Brander C. The 2019 Optimal HIV CTL epitopes update: Growing diversity in epitope length and HLA restriction. In: Yusim K, Korber BTM, Brander C, Barouch D, de Boer R, Haynes BF, Koup R, Moore JP, Walker BD, Watkins DI, editors. HIV Molecular Immunology 2018. Los Alamos, NM: Los Alamos National Laboratory, Theoretical Biology and Biophysics; 2019. p. 3–27.

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14. Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J Clin Invest. 2020;130(5)2620–2629. doi: 10.1172/JCI137244 Epub 2020 Mar 27. 32217835

15. Friberg H, Beaumier CM, Park S, Pazoles P, Endy TP, Mathew A, et al. Protective versus pathologic pre-exposure cytokine profiles in dengue virus infection. PLoS Negl Trop Dis. 2018;12(12):e0006975. doi: 10.1371/journal.pntd.0006975 eCollection 2018 Dec. 30557313

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