Biological sex impacts COVID-19 outcomes
Autoři:
Sabra L. Klein aff001; Santosh Dhakal aff001; Rebecca L. Ursin aff002; Sharvari Deshpande aff001; Kathryn Sandberg aff003; Franck Mauvais-Jarvis aff004
Působiště autorů:
W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
aff001; Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
aff002; Departments of Medicine and Nephrology & Hypertension, Georgetown University, Washington, DC, United States of America
aff003; Diabetes Discovery & Sex-Based Medicine Laboratory, Section of Endocrinology, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
aff004; Southeast Louisiana Veterans Health Care System Medical Center, New Orleans, Louisiana, United States of America
aff005
Vyšlo v časopise:
Biological sex impacts COVID-19 outcomes. PLoS Pathog 16(6): e1008570. doi:10.1371/journal.ppat.1008570
Kategorie:
Opinion
doi:
https://doi.org/10.1371/journal.ppat.1008570
Souhrn
The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male–female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.
Klíčová slova:
diabetes mellitus – Health care facilities – Immune response – Kidneys – Mouse models – New York – SARS – SARS coronavirus
Zdroje
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