Rozdiely v incidencii a biologických charakteristikách karcinómu prsníka medzi rómskymi a nerómskymi pacientkami na Slovensku

English version

Autoři: M. Reckova ^1,2; J. Mardiak ¹; L. Plank ³; M. Vulevova ⁴; S. Cingelova ¹; M. Mego ¹
Působiště autorů: nd Department of Medical Oncology, Faculty of Medicine, Comenius University, National Cancer Institute, Bratislava, Slovak Republic ¹; POKO Poprad, s. r. o., Slovak Republic ²; Department of Pathology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Slovak Republic ³; Department of Pharmacy, Comenius University in Bratislava, Slovak Republic ⁴
Vyšlo v časopise: Klin Onkol 2017; 30(1): 48-54
Kategorie: Původní práce
doi: https://doi.org/10.14735/amko201748

Souhrn

Východiská:
Rómovia tvoria jednu z najväčších etnických minorít na Slovensku. Existujú údaje o vyššej prevalencii prenosných ochorení u Romov, zaťiaľčo údaje o nádorových ochoreniach v rómskej populácii známe nie sú. Cieľom tejto štúdie bolo porovnať rozdiely v incidencii a patologických charakteristikách medzi rómskymi a nerómskymi pacientkami s nádorom prsníka na Slovensku. Materiál a metódy: Na základe údajov o pohlaví, dátumu narodenia a bydliska sme spárovali databázu HER2 registra v rokoch 2011–2013 s posledným sčítaním ľudu Slovenskej republiky v roku 2011, a identifikovali sme rómske a nerómske pacientky s karcinómom prsníka. Výsledky: Identifikovali sme 32 rómskych a 5 775 nerómskych pacientok s karcinómom prsníka. Vekovo-štandardizovaná incidencia karcinómu prsníka bola 2,12-krát vyššia u nerómiek v porovnaní s rómkami (36 vs. 17 na 100 000 ľudí). Rómky boli v čase diagnózy mladšie v porovnaní s neRómkami (medián 49 vs. 61 rokov; p = 0,00001). Rómky mali v porovnaní s nerómkami viac hormón-receptor negatívnych (34,4 vs. 18,1 %; p = 0,03) a triple-negatívnych nádorov (28,1 vs. 12,3 %; p = 0,01), a tieto rozdiely zostali štatisticky signifikantné v multivariačnej analyze. Záver: Poprvykrát sme zistili rozdiely v incidencii a biologických charakteristikách u rómskych žien s karcinómom prsníka v porovnaní s nerómskymi pacientkami. Na základe zistených údajov predpokladáme, že rómske pacientky s karcinómom prsníka sú mladšie v čase diagnózy, majú nižšiu vekovo-štandardizovanú incidenciu a biologicky agresívnejšie nádory v porovnaní s nerómkami.

Kľúčové slová:
nádory prsníka – incidencia – Rómovia – epidemiológia

M. R., J. M., S. C. a M. M. deklarujú, že v súvislosti s predmetom štúdie nemajú žiadne komerčné záujmy. L. P. je odborný garant, zamestnaný a spolumajiteľ Martinského bioptického centra, s.r.o.; v minulosti dostal finančnú odmenu od spoločnosti Roche Slovensko. M. V. bola v posledných 2 rokoch zamestnaná v spoločnosti Roche Slovensko.

Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do biomedicínských časopisů.

Obdrženo:
29. 8. 2016

Přijato:
26. 10. 2016

Zdroje

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