Iron deficiency related anaemia and geriatric medicine

Česká verze

Authors: H. Meluzínová; P. Weber; D. Weberová
Authors place of work: Klinika interní, geriatrie a praktického lékařství LF MU a FN Brno
Published in the journal: Geriatrie a Gerontologie 2014, 3, č. 4: 179-182
Category: Přehledové články

Summary

Anemia in the elderly is common and is usually mild and in most cases > 100 g /l. However, it is not only associated with higher morbidity and even mortality. The prevalence of new anemia increases compared to 65–69–year–old (3–4 %) of people for the 85th year at the age of two to three times. If it is determined microcytic anemia, you need to carefully search for a possible source of bleeding.

The authors point to the complexity and interconnectedness of some events in the development of microcytic anemia in some aspects, risks and pitfalls microcytic anemia and its relationship with anemia of chronic disease. They also indicate the general characteristics of the anemia, the prevalence of iron metabolism in relation to erythropoiesis, including clinical and laboratory typing, diagnosis and treatment of seniors.

Keywords:
age – anemia – iron – transferrin – ferritin

Zdroje

1. Andro M, Le Squere P, Estivin S, Gentric A. Anaemia and cognitive performances in the elderly: a systematic review. Eur J Neurol 2013; 20(9): 1234–1240.

2. Artz AS, Fergusson D, Drinka PJ et al. Mechanisms of unexplained anemia in the nursing home. J Am Geriatr Soc 2004; 52(3): 423–427.

3. Beghé C(1), Wilson A, Ershler WB. Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature. Am J Med 2004; 116, Suppl 7A: 3S–10S.

4. Beutler E, Waalen J. The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood 2006; 107(5): 1747–1750.

5. Clark SF. Iron deficiency anemia. Nutr Clin Pract 2008; 23(2): 128–141.

6. den Elzen WP, Gussekloo J. Anaemia in older persons Neth J Med 2011; 69(6): 260–267.

7. den Elzen WP, Willems JM, Westendorp RG, et al. Effect of anemia and comorbidity on functional status and mortality in old age: results from the Leiden 85-plus Study. CMAJ 2009; 181(3): 151–157.

8. Ershler WB, Sheng S, McKelvey J et al. Serum erythropoietin and aging: a longitudinal analysis. J Am Geriatr Soc 2005; 53: 1360–1365.

9. Ferrucci L, Semba RD, Guralnik JM, et al. Proinflammatory state, hepcidin, and anemia in older persons. Blood 2010; 115(18): 3810–3816.

10. Guralnik JM(1), Eisenstaedt RS, Ferrucci L et al. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 2004; 104(8): 2263–2268.

11. Huang X, Qu X, Yan W et al. Iron deficiency anaemia can be improved after eradication of Helicobacter pylori. Postgrad Med J 2010; 86(1015): 272–278.

12. Joosten E, Hiele M, Ghoos Y et al. Diagnosis of iron-deficiency anemia in a hospitalized geriatric population. Am J Med 1991; 90(5): 653–654.

13. Klip IT, Comin–Colet J, Voors AA et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am Heart J 2013; 165(4): 575–582.

14. Liu K, Kaffes AJ. Iron deficiency anaemia: a review of diagnosis, investigation and management. Eur J Gastroenterol Hepatol 2012; 24(2): 109–116.

15. Novotný J. Sideropenická anemie. Med. Pro Praxi 2007; 4(11): 390–394.

16. Penka M, Tesařová E a kol. Hematologie a transfuzní lékařství I – Hematologie. Praha: Grada Publishing 2011; 421 s.

17. Perlstein TS, Pande R, Berliner N, Vanasse GJ. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation. Blood 2011; 117, 10, 2800–2806.

18. Price EA, Mehra R, Holmes TH, Schrier SL. Anemia in older persons: etiology and evaluation. Blood Cells Mol Dis 2011; 46(2): 159–165.

19. Qu XH, Huang XL, Xiong P et al. Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis. World J Gastroenterol 2010; 21(16): 7, 886–896.

20. Roller RE, Iglseder B, Dovjak P et al. Blutungskomplikationen bei geriatrischen Patienten unter oraler Antikoagulation-Aspekte der Polypragmasie. Wien Med Wochenschr 2010; 160(11–12): 270–275.

21. Tettamanti M, Lucca U, Gandini F et al. Prevalence, incidence and types of mild anemia in the elderly: the “Health and Anemia” population-based study. Haematologica 2010; 95(11): 1849–1856.

22. Triadafilopoulos G. Management of lower gastrointestinal bleeding in older adults. Drugs Aging 2012; 29(9): 707–715.

23. Vanasse GJ, Berliner N. Anemia in elderly patients: an emerging problem for the 21st century. Hematology Am Soc Hematol Educ Program 2010; 1: 271–275.

24. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005; 352(10): 1011–1023.

25. Yang Y, Li H, Li B et al. Efficacy and safety of iron supplementation for the elderly patients undergoing hip or knee surgery: a meta-analysis of randomized controlled trials. J Surg Res 2011; 171(2): 201–207.