Search results: (10000)
News Domestic application of biological asthma treatment improves quality of life and reduces doctor visits
The benefits of the possibility of home application of omalizumab, a monoclonal antibody indicated for patients with severe allergic asthma, are summarized by Dr. Jakub Novosad, Ph.D., from the Institute of Clinical Immunology and Allergology, Charles University Medical Faculty and University Hospital Hradec Králové.
News How and when does the reaction to gluten begin in coeliac disease? A new Canadian study offers potential answers
As is well known, coeliac disease is a systemic autoimmune disorder characterised by damage to intestinal epithelial cells (IEC). Canadian researchers have sought to uncover the relationship between intestinal epithelial cells and T lymphocyte activation in this disease. The results of their work provide hope for the potential development of an effective therapy.
News Can Antihypertensives Reduce the Risk of Dementia? The Answer Suggests the Angiotensin Hypothesis and a Post-Hoc Analysis of an Observational Study
The use of antihypertensives that do not reduce angiotensin II levels, such as angiotensin receptor blockers (ARBs, i.e., sartans) and calcium channel blockers (CCBs), has been associated with a lower risk of dementia in studies. In the research cited below, the authors aimed to determine whether this effect persists longer than the follow-up period in previous studies.
News Use of Tiapride in the Treatment of Behavioral Disorders in Geriatric Patients
Hand in hand with the increasing number of people reaching an older age, there is also a rise in the occurrence of dementia. It affects the lives of patients and their families in many ways. A significant problem can be behavioral disorder, which needs to be treated adequately and promptly to prevent issues such as injuries.
News Incontinence as a Consequence of Surgical Procedure on the Prostate
Despite the advent of new surgical methods, urinary incontinence after prostate procedures remains a clinically significant iatrogenic complication. For patients, it represents a significant stress factor that carries physical and psychosocial consequences.
News New scoring system for predicting long-term survival of AML patients over 70 years and suitable for intensive chemotherapy
Based on the analysis of data from 3 large European registries (DATAML, SAL, and PETHEMA), a prognostic score for 5-year survival was created and validated for patients with acute myeloid leukemia (AML) who were given intensive chemotherapy. The ESS70+ score, determined based on parameters known at the time of diagnosis, is easily usable in routine practice for estimating overall survival of older AML patients and facilitates decisions about intensive chemotherapy.
News Wireless Smart Devices Monitor Health by Detecting Sounds
The human body continuously emits various forms of acoustic-mechanical signals that can provide important information about its health. Researchers from Northwestern University in the USA have developed miniature wearable devices (wearables) capable of simultaneously detecting sounds from multiple locations on the body, thereby continuously monitoring the health of the wearer. In a pilot project, the devices were tested on prematurely born infants with breathing and intestinal motility disorders and on adults with chronic lung diseases.
News How Does Artificial Intelligence Help in Drug Development?
In recent years, technologies leveraging artificial intelligence have transitioned from potentially interesting novelties to real clinical development programs. What can artificial intelligence offer the development of new drugs?
News Targeted Treatment and Quality of Life in Patients with Follicular Lymphoma
The GALLIUM clinical trial evaluated chemotherapy in combination with targeted treatment using rituximab or obinutuzumab in previously untreated patients with advanced follicular lymphoma (FL). A secondary aim of the study was to assess the health-related quality of life. The results of the analysis were recently published in the journal Annals of Hematology.
News Will 3D Printable Tissue Adhesives Replace Stitches and Clips?
3D printing technology is slowly making its way into more and more areas of healthcare. In February 2024, a scientific team from the Massachusetts Institute of Technology (MIT) published a study in the journal Nature Communications focusing on the possibilities of 3D printing tissue adhesives and personalized patches with adjustable internal structures. These could therefore become a suitable alternative to the traditional surgical sutures and clips used for joining tissues.
News New Technology Teaches Healthcare Professionals to Deliver Messages Patients Don't Want to Hear
Communication with patients and their relatives is often very challenging for doctors and nurses, especially when the patient or their family member is experiencing strong emotions. A new technology from the startup ComGuide is here to help healthcare professionals practice how to communicate most effectively. Jan Hrdlička, the co-author, explained how exactly this technology works, who it is suitable for, and how it was developed and continues to evolve.
News Can Artificial Intelligence Help Personalize Treatment for Cardiology Patients?
According to data from the World Health Organization (WHO), cardiovascular diseases (CVDs) claim an estimated 17.9 million lives annually worldwide, making them the leading cause of death. More than 4 out of 5 of these deaths are due to heart attacks and strokes, and one-third occur in people under the age of 70. An innovative project called NextGen will newly address cardiovascular diseases. Its goal is to use artificial intelligence (AI) and patient health information and genetic profiles to personalize their treatment. The project received 7.6 million euros from the EU program Horizon Europe and will be led by a 21-member consortium including representatives from the European Society of Cardiology (ESC).
News Hypotension during treatment with sacubitril/valsartan: practical tips for prevention and management
Despite the undeniable benefits of sacubitril/valsartan in terms of morbidity and mortality in patients with chronic heart failure, its administration can be complicated by side effects. The most common of these is hypotension. Although it is an unpleasant complication, it does not – and should not – always be a reason to discontinue therapy. Fear of hypotension should not lead to not prescribing sacubitril/valsartan at all. We provide practical guidance on how to approach this clinical situation.
News INTERACTIVE CASE STUDY: Treatment of glaucoma medications without preservatives – current trend
The use of glaucoma medications without preservatives has been a trend in recent years. You can try their clinical application in the role of a prescribing doctor in an interactive case study. Practical information about this popular local treatment is based on the evidence-based medicine foundation, provided by its author MUDr. Petr Výborný, CSc., from the Eye Clinic of the 1st Faculty of Medicine, Charles University and University Military Hospital in Prague.
News Scientists Create First Functional Brain Tissue Using 3D Printing
A research team from the University of Wisconsin-Madison has successfully printed the first ever functional brain tissue using a commercial 3D printer in their laboratory. This breakthrough may be beneficial not only for scientists studying the pathogenesis of neurological and neurodevelopmental diseases but could even mark the beginning of a journey towards a deeper understanding of how neurons function, how brain development occurred, and how different parts of the brain communicate with each other.
News Ultrasound in a Patch – Smart System Capable of Monitoring Patient During Regular Activities
A team of scientists from the University of California, San Diego, has developed a miniature autonomous ultrasound system that, when attached to the skin, can visualize tissue located deep beneath the body’s surface. It could be used for continuous monitoring of blood pressure, heart activity, and respiratory parameters in real time, whether during regular activities or intense physical exertion.
News Artificial Intelligence Helps in Selecting Influenza Strains for Vaccine Production
Vaccination is one of the most important and effective preventive measures in the fight against seasonal epidemics caused by influenza viruses each year. For vaccines to work, they must match the currently circulating influenza strains. The timely selection of appropriate influenza strains, which will be the most widespread in the population in the upcoming period, and their yield are crucial for vaccine development. The new MAIVeSS (Machine-learning Assisted Influenza Vaccine Strain Selection) method, which uses artificial intelligence and machine learning algorithms for direct analysis of clinical samples, could help with this process.
News Treatment of Schizophrenia in a Patient at Risk of Developing Metabolic Syndrome – Interactive Case Study
A 34-year-old man has been under psychiatric care for 3 years due to a psychotic disorder. Three years ago, he had his first short hospitalization due to marked paranoid symptoms: feelings of being watched, eavesdropping, auditory hallucinations of an imperative nature...