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News Mucormycosis Associated with COVID-19 –⁠ Case Report and Review of Current Knowledge

Systemic corticosteroids are among the treatments used for patients with severe COVID-19. These patients are at increased risk of opportunistic bacterial and fungal infections. Pulmonary aspergillosis is particularly serious, while mucormycosis is relatively rare.

Source: Anti-Infectives 20. 10. 2021

News Infographic and Commentary from Practice: Reasons and Pathways for Patients to Biological Treatment of Asthma

For asthma patients with the most severe forms of the disease to access targeted biological treatment, they must undergo examination at one of the specialized centers for severe asthma. To facilitate this pathway, a recommended procedure has been issued, from which we present a pragmatic extract for practice in the form of a clear infographic.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 28. 4. 2023

News Romosozumab vs. Teriparatide in Sequential Treatment of Osteoporosis in Women with a History of Fracture

The STRUCTURE study observed the effect of romosozumab and teriparatide on bone density in postmenopausal women with osteoporosis transitioning from bisphosphonate treatment over a 12-month period.

Source: Osteoporosis – Trends in Sequential Therapy 14. 11. 2023

News Combination of SGLT2 inhibitors with metformin in terms of mechanism of action

In the treatment of type 2 diabetes (T2D), metformin is recommended as the first-line drug alongside lifestyle modification. However, with disease progression, monotherapy is often insufficient. SGLT2 inhibitors (SGLT2i) are recommended in combination with metformin in light of recent findings, as their mechanism of action is independent of insulin effect. They have shown a reduction in cardiovascular (CV) risk in diabetics with CV disease.

Source: Diabetes 18. 3. 2020

News Targeted Treatment of HER2-Positive Breast Tumors –⁠ Updates from ESMO 2020 Congress

The recent European Society for Medical Oncology (ESMO) Congress took place virtually. We bring you a brief summary of the presentations related to the treatment of HER2-positive breast tumors.

Source: Breast Carcinoma 11. 1. 2021

News Post hoc Analysis of the FRAME Study –⁠ Romosozumab in the Treatment of Osteoporosis in the European Population

An interesting finding from the FRAME study, which evaluated the treatment of postmenopausal women with osteoporosis using romosozumab, was the significant differences in fracture incidence among patients from various geographic regions. The following post hoc analysis specifically focused on data from European women.

Source: Osteoporosis – Trends in Sequential Therapy 14. 11. 2023

News Incidence of CV Events, Malignancies, and Venous Thromboembolism in Patients with RA According to Baseline CV Risk and Administered Treatment

An international team of experts evaluated the impact of cardiovascular (CV) risk on the incidence and risk of major CV events, malignancies, and venous thromboembolism (VTE) in patients with rheumatoid arthritis (RA) treated with tofacitinib compared to tumor necrosis factor (TNF) inhibitors, depending on the level of CV risk at the initiation of this therapy. The authors used data from the ORAL Surveillance study.

Source: Arthritis 27. 7. 2022

News Administration of aPCC as a Prevention of Bleeding After Major Cardiac Surgical Procedures

The possibility of actively preventing severe bleeding after a major cardiac surgical procedure using cardiopulmonary bypass (CPB) by administering a concentrate of activated procoagulant complex seems feasible, although a larger study will be needed to confirm its effect.

Source: Hemophilia 22. 11. 2021

News Can Antihypertensives Reduce the Risk of Dementia? The Answer Suggests the Angiotensin Hypothesis and a Post-Hoc Analysis of an Observational Study

The use of antihypertensives that do not reduce angiotensin II levels, such as angiotensin receptor blockers (ARBs, i.e., sartans) and calcium channel blockers (CCBs), has been associated with a lower risk of dementia in studies. In the research cited below, the authors aimed to determine whether this effect persists longer than the follow-up period in previous studies.

Source: Sartans in the Treatment of Hypertension 14. 8. 2023

News Fixed Combination of Tramadol/Paracetamol in the Treatment of Chronic Lower Back Pain and Its Effect on Apathy in Chronically Algic Patients

Long-term chronic pain is associated with apathy, loss of motivation, and depression in patients. However, these comorbidities of chronic pain and their interconnections are still insufficiently explored. The aim of the Japanese study was to evaluate the prevalence of apathy in patients with chronic low back pain (LBP) and the therapeutic efficacy of the fixed combination of tramadol/paracetamol in treating this pain and its effect on apathy in LBP patients.

Source: Pharmacotherapy of Pain 9. 10. 2020

News New Natural Method for Prevention and Treatment of House Dust Mite Allergy

House dust mites are among the most common triggers of respiratory allergies. Until now, therapy has primarily focused on alleviating allergy symptoms. The aim of the new natural-based method is to eliminate the etiology of the issues, specifically the house dust mites themselves.

Source: Dust Mite Allergy 6. 10. 2020

News Benefits of Physical Activity for Individuals with Hemophilia –⁠ Recommendations of the MEMO Group

Regular physical activity can increase joint stability and function in individuals with hemophilia, reduce the risk of injury, improve quality of life, and have other positive effects. However, according to recent findings, a regular exercise program is not sufficiently emphasized in comprehensive hemophilia therapy. Therefore, a group of Italian experts has created a consensus summarizing current knowledge about the benefits of exercise for individuals with hemophilia and recommendations for physical activity.

Source: Hemophilia with Movement 25. 11. 2022