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News Impact of Administering Omega-3 Fatty Acids on the Risk of Metabolic Syndrome in Patients with Schizophrenia
The aim of the Polish clinical study OFFER was to assess the possibility of influencing the risk of developing metabolic syndrome (MetS) and some of its individual components in patients with first-episode schizophrenia by supplementing with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
News INFOGRAPHIC: Which treatment to choose in the 1st line for a patient with type 2 diabetes?
Diabetes mellitus is a complex chronic disease that requires continuous treatment and a strategy to reduce associated risks beyond mere glycemic control. Comorbidities and the risk of complications are key elements in deciding the choice of therapy for type 2 diabetics. This fact is also considered by the American Diabetes Association (ADA) in its annually published standards of care for patients with diabetes, which brought several changes in 2022.
News ESC 2022: Initiating Gliflozin in HFpEF During Hospitalization Can Benefit the Patient. This is Also Evidenced by Experience from the USA
Based on evidence from clinical studies, gliflozins are currently being introduced into practice for heart failure with preserved ejection fraction (HFpEF) as early as hospitalization. Sharing experiences is therefore very valuable. Several symposia at the ESC 2022 congress focused on the issue of introducing these drugs into HF treatment, some of which also included illustrative case studies. For example, the case of a patient with HFpEF from the USA demonstrated the early initiation of empagliflozin during hospitalization.
News Where radical surgery cannot be performed in the subhepatic region or liver, there is room for radiation treatment
Proton radiotherapy continues to expand its indications in the treatment of oncological diseases. In the following interview, we focus on its role in treating tumors in the subhepatic region. MUDr. Pavel Vítek, Ph.D., MBA, from the Proton Center Prague (PTC), shared his perspective on this modality and his experiences at his workplace.
News Atectura® and Enerzair®: new fixed dual and triple combination in the treatment of bronchial asthma
In mid-2020, the European Commission approved two new fixed combinations of drugs by Novartis for patients with uncontrolled asthma – the dual combination Atectura® (LABA+ICS) and the triple combination Enerzair® (LABA+LAMA+ICS) for inhalation once daily using the Breezhaler® inhaler.
News Gene Therapy for Hemophilia A: What is the Expression of Factor VIII Using the Adeno-Associated Viral Vector SPK-8011?
The goal of gene therapy for hemophilia A is to safely transfer stable and durable expression of coagulation factor VIII (FVIII), which predictably improves the bleeding phenotype at the lowest possible vector dose. Updated data from a study examining the use of the adeno-associated viral vector (AAV) SPK-8011 were presented during the virtual congress of the International Society on Thrombosis and Haemostasis (ISTH) 2021.
News Mass in the Left Atrium Appendage - Case Report
A symptomatic mass in the left atrial appendage warrants thorough investigation and radical treatment – unless it is in the heart of a polymorbid patient, as was the case in the following report.
News Interactive Case Study: Use of Cannabis Extract for Local Treatment of Neuropathic Pain
We have been using cannabis for pain treatment for several years. We also have good experiences with it in difficult-to-control symptoms of neuropathic pain, as illustrated in the following case study. Until recently, our patients only used cannabis orally or via vaporization. With the availability of cannabis extracts, a new option has emerged – local therapy.
News CASE STUDIES on the topic of progressing interstitial lung processes
This page serves as a hub for case studies on the topic of progressing interstitial processes. The case studies aim to provide a multidisciplinary view on the rare disease topic of IPP.
News Through Obstacles to the Stars – Path to Developing a Healthy Gut Microbiota in Children: What Blocks It and What Helps?
The gut microbiota is acquired by an individual during the first 2 years of life. The main source is the mother’s microbiota. Obstacles to the formation of an adequate microbiota include inappropriate composition of the mother’s microbiota, absence of vaginal birth and breastfeeding, as well as artificial feeding and antibiotic treatment in the child. We provide a summary of current findings on the adverse effects of planned cesarean sections on the child’s microbiome, as recently published in Critical Reviews in Microbiology.
News Noonan's Syndrome – History and Present
The genetically determined syndrome linking congenital heart defect with a typical facial phenotype is named after Jacqueline Noonan, a pediatric cardiologist who practiced in the second half of the 20th century. She was the first to recognize and describe it. In the following text, we will briefly introduce it and discuss the circumstances of its discovery.
News Smouldering Multiple Sclerosis: How Can MRI Help in Its Identification?
With the changing understanding of the etiopathogenesis of multiple sclerosis, several new questions arise. One of them is the question of identifying the progressive phase of the disease. Can magnetic resonance imaging (MRI) help in this regard?
News Screenings of Lung Cancer and COPD are Significant. What Do the Latest Data from Czechia Say?
At the end of January, an expert seminar was held, focusing on updates in the treatment of respiratory diseases. During this event, the head of the Pulmonary Clinic at LF UK and FN Hradec Králové, Associate Professor MUDr. Vladimír Koblížek, Ph.D., gave a lecture on the current Czech findings from lung cancer screenings and a project aimed at the early detection of chronic obstructive pulmonary disease (COPD).
News Newer Beta Blockers Offered for Use in Atherosclerosis Prevention
An article highlighting recent scientific findings on the beneficial effects of beta-blockers (BB) directly on the arterial wall and the potential benefit for the prevention of atherosclerotic cardiovascular disease (ASCVD) by adding BB to already established strategies for treating dyslipidemia and diabetes was published this year in the journal Current Atherosclerosis Reports.
News Impact of Chronic Urticaria on Patients' Quality of Life and Society
An international team of dermatologists has mapped out the impact of chronic urticaria on various aspects of patients' lives and the economic burden this long-term disease, without available causal treatment, represents for society, according to available literature.
News Prof. Hana Rosolová: According to recent studies, caution is needed with beta-blockers only in severe cases of asthma and COPD
Beta-blockers (BB) are among the most widely used drug groups in cardiology. While their position is clear in some indications, it is debated in others. Additionally, individual BBs differ in various aspects, which plays an important role in selecting the right treatment for a particular patient. We discussed some current topics related to beta-blockers with the head physician of the Center for Preventive Cardiology of the 2nd Department of Internal Medicine LF UK and FN Plzeň Prof. MUDr. Hana Rosolová, DrSc., FESC.
News Mechanisms of Cardioprotective Effects of SGLT2 Inhibitors
Inhibitors of sodium-glucose cotransporter 2 (SGLT2i, gliflozins) are a relatively new group of medications used in the treatment of type 2 diabetes mellitus (T2DM). Their clinical use is supported by the results of extensive clinical studies, which have particularly demonstrated their cardioprotective and renoprotective effects.
News Changes in Blood Count as Possible Prognostic Markers of Response to Panitumumab in Patients with mCRC
As part of the VALENTINO study with panitumumab in patients with metastatic colorectal cancer without RAS mutation, the connection between certain blood count parameters associated with inflammation and patient prognosis was investigated.
News Can the Use of Statins Help Reduce the Risk of Dementia?
A meta-analysis published last year by Taiwanese experts evaluated the connection between the use of statins and the incidence of dementia. What conclusions did the authors reach?
News Hybrid Cooperating Complexes in Osteoarthritis Treatment
Intra-articular application of corticosteroids and hyaluronic acid is part of the treatment of osteoarthritis (OA) in patients for whom oral or topical treatment does not provide sufficient response. The following text addresses the lubricating and protective properties of synovial fluid and the associated choice of suitable intra-articular viscosupplementation, with an emphasis on innovative molecules with high concentrations of hyaluronic acid and low viscosity.
News Use of Bilastine in Pediatrics − Pathway to Improving Concentration and Performance of Young Allergy Sufferers
In the treatment of allergic diseases, especially in children, safety, good tolerability, simple dosing regimen, and non-sedative effects are the basic requirements for administered medications. Sedative side effects of treatment have a negative impact on sleep patterns and subsequently on children's performance in school. European professional societies recommend the use of modern second-generation antihistamines in the treatment of children. Studies confirm that bilastine, which meets these requirements, should be among the first-choice drugs.