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News When to Switch to Second-Line Treatment for Primary Biliary Cholangitis?

In patients with primary biliary cholangitis (PBC), the response to ursodeoxycholic acid (UDCA) treatment is an important prognostic indicator. To identify patients with an insufficient response to this modality who require second-line therapy, the best practice is to assess the biochemical response to UDCA after 12 months of treatment. A validated and easy-to-use tool is the determination of serum alkaline phosphatase (ALP) activity and serum total bilirubin concentration. Although treatment response to UDCA is commonly checked after 12 months, a 6-month check has the same discriminatory value.

Source: Primary Biliary Cholangitis 10. 12. 2020

News Is the efficacy of bisoprolol in secondary prevention of acute myocardial infarction in patients after percutaneous coronary intervention comparable to carvedilol?

Beta-blockers (BB) are recommended for all patients after percutaneous coronary intervention (PCI) as part of secondary prevention of acute myocardial infarction (AMI). The study presented below compared the efficacy of carvedilol –⁠ a vasodilating beta-blocker, whose benefit in this indication was confirmed by a randomized clinical trial –⁠ with the effect of bisoprolol.

Source: Cardiovascular Continuum 26. 1. 2021

News Cardiovascular Safety of Tofacitinib in Real-World Clinical Practice –⁠ Results of the STAR-RA Study

Recent results from the ORAL Surveillance clinical trial have raised concerns about the cardiovascular adverse effects of tofacitinib in patients with rheumatoid arthritis. A comprehensive analysis of real-world clinical practice data, involving nearly 13,000 patients, focused on the cardiovascular safety of tofacitinib for this indication.

Source: Arthritis 29. 5. 2022

News The Benefit of Dabigatran Over Warfarin Is Greater in Patients with Atrial Fibrillation and Diabetes Than in Nondiabetics

As early as 2015, an analysis of the results of the RE-LY study in patients with atrial fibrillation showed that the reduction in absolute risk of embolic events with dabigatran compared to warfarin is greater in patients with diabetes than in those without diabetes.

Source: Anticoagulant Treatment 24. 4. 2020

News Safety and efficacy of dabigatran and other NOACs compared with warfarin in patients with atrial fibrillation –⁠ results of a large long-term prospective study

Anticoagulant therapy is key in the prevention of strokes in patients with atrial fibrillation. Until the introduction of new oral anticoagulants (NOACs), warfarin was the first-choice drug for these patients, but unlike NOACs, it requires careful dose titration and effect monitoring. The safety and benefits of using various anticoagulants were examined in the study below.

Source: Anticoagulant Treatment 25. 5. 2020

News Patient with generalized malignant melanoma treated with nivolumab in the first line

A 75-year-old patient was referred for examination at the dermato-oncology clinic of the Dermatology Clinic of VFN in September 2016. He was being treated for ICHS and had undergone prostate surgery for hyperplasia in 2013.

Source: Case Studies from Immunooncology 10. 9. 2020

News Comparison of the Effectiveness of Different Types of Toothbrushes in Orthodontic Patients

The aim of the study cited below was to evaluate the efficiency of a manual orthodontic brush, an electric toothbrush with an oscillating head, and a sonic toothbrush in controlling plaque, gingivitis, and interproximal bleeding in patients undergoing orthodontic treatment with fixed appliances and to compare their relative effectiveness.

Source: Dental Care 10. 5. 2023

News Mass in the Left Atrium Appendage -⁠ Case Report

A symptomatic mass in the left atrial appendage warrants thorough investigation and radical treatment –⁠ unless it is in the heart of a polymorbid patient, as was the case in the following report.

Source: Thromboprophylaxis 14. 9. 2020

News Von Willebrand Disease as a Cause of Abnormal Uterine Bleeding

Abnormal uterine bleeding constitutes a large portion of complaints among women of reproductive age. This type of bleeding is typical for von Willebrand disease (vWD), but also for other types of coagulation disorders. So, is vWD more frequent in women with abnormal uterine bleeding than in the general population?

Source: Von Willebrand Disease 16. 7. 2021

Články časopisu Inherited Thrombophilic Tendencies and Oral Contraceptive Pills

Author of the article: I. Hadačová Source: Česko-slovenská pediatrie | 6/2010 19. 8. 2010

News Subcutaneous Immunoglobulin Therapy in Patients with Secondary Immunodeficiency –⁠ Real-World Data

Even in patients with secondary immunodeficiency (SID), immunoglobulin substitution can be indicated. Intravenous (IVIG) therapy is considered effective based on studies, but subcutaneous (SCIG) therapy is only based on experiences with patients having primary immunodeficiency (PID). The Italian study presented below, therefore, investigated the efficacy and safety of SCIG in patients with SID.

Source: Primary and Secondary Immunodeficiencies 2. 10. 2023

Články časopisu Implementation and applications of robotic surgery within gynecologic oncology and gynecology; analysis of the first thousand cases

Author of the article: C. Lönnerfors, J. Persson Source: Česká gynekologie | 1/2013 1. 3. 2013

News Could candesartan counteract adverse intestinal changes induced by hypertension?

An experimental study published last year was the first to show that administration of candesartan may increase the tightness of epithelial junctions in the intestinal wall and positively affect the composition of the microflora. It expands the knowledge of recently described pathophysiological changes in the gut associated with hypertension.

Source: Sartans in the Treatment of Hypertension 6. 3. 2020

News Safety and Efficacy of Combination Therapy for Allergic Rhinitis Compared to Monotherapies and Placebo

Combination therapy of antihistamine and corticosteroid is a promising alternative for patients suffering from seasonal allergic rhinitis. A phase II clinical study aimed to determine the effective dosage, efficiency, and safety of combination therapy compared to monotherapies and placebo.

Source: Life Without Allergic Rhinitis 7. 6. 2022

News Prenatal Phenotype of Children with Noonan Syndrome

Until recently, the various phenotypes of RASopathies were clinically diagnosed only after birth. However, we are now striving for the earliest possible diagnosis, sometimes even prenatally. Ultrasound examination of the fetus during screening tests, focusing on certain characteristic morphological changes, plays a crucial role in this. In the case of pathological findings on imaging methods, molecular genetic testing and monitoring of pregnancy in specialized centers are indicated.

Source: Growth Disorders 4. 5. 2021