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News Asthma is not a risk factor for a severe course of COVID-19
According to the statement of the Czech Initiative for Asthma from April 2020, the disease COVID-19 caused by the new type of coronavirus does not pose significantly greater danger for people with asthma than for the general population. It is, however, necessary to adhere to the prescribed treatment and keep asthma under control. The Journal of Allergy and Clinical Immunology provides an explanation for this surprising phenomenon. It is the reduced expression of ACE2 receptors in people with asthma and allergies, as shown by a new study involving three cohorts of pediatric and adult patients. The SARS-CoV-2 virus uses ACE2 receptors to enter the host cell.
News INFOGRAPHIC: Post-Induction Therapy for AML – Current Guidelines
What are the recommended therapeutic modalities for consolidation and maintenance therapy of acute myeloid leukemia (AML) in patients over 60 years of age? We present a clear therapeutic algorithm according to the current recommendations of the American National Comprehensive Cancer Network.
News Deficit Alpha-1-Antitrypsin as an Underestimated Problem? What a Survey Among European Experts Revealed
Alpha-1-antitrypsin deficiency (AATD) is a congenital disorder caused by mutations in the SERPINA1 gene. Although it is very well described, it is considered underdiagnosed and undertreated. A recent international survey conducted among specialists on this issue aimed to determine the current situation in Europe.
News The Immune System in the Pathophysiology of ITP
From the perspective of the pathophysiology of immune thrombocytopenia (ITP), it appears that the etiology of this disease is very complex and involves both antibody and cellular immunity.
News How TPO-RA Drugs Fared in Meta-Analyses of Safety and Efficacy in ITP Patients
Meta-analyses regarding the use of thrombopoietin receptor agonists (TPO-RA) evaluated their efficacy and safety in the treatment of primary immune thrombocytopenia over long-term follow-ups. What findings did they uncover?
News Can Thyroid Hormone Supplementation Reduce the Risk of Cognitive Disorders?
The recent systematic literature review presented below, published by authors from the California Institute of Behavioral Neurosciences and Psychology (CIBNP), focused, among other things, on potential associations between hypothyroidism and dementia and the impact of related therapeutic interventions in terms of improving cognitive functions.
News Subcutaneous zilucoplan – the end of necessary “trips” to the hospital for myasthenia gravis patients?
A study recently published in Lancet Neurology demonstrated the efficacy and safety of the subcutaneously administered complement component C5 inhibitor – zilucoplan – in the treatment of myasthenia gravis (MG). This drug has the potential to alleviate the severity of this disease and improve the quality of life of patients.
News Long-term Safety of Dupilumab in Adult Patients with Moderate to Severe Atopic Dermatitis
Moderate to severe atopic dermatitis (AD) often requires systemic therapy. The long-term safety of dupilumab in patients with this condition was evaluated in an open-label extension (OLE) of the LIBERTY AD study, the results of which were recently published.
News Will up-titration or combination with bisoprolol help to better control hypertension in amlodipine users?
Will patients with hypertension who do not achieve control of this condition with amlodipine at a dose of 5 mg benefit more from up-titration or combining it with bisoprolol? The answer to this question was sought in a study published this year by German authors.
News Analysis of the Benefits of Combining Enalapril/Bisoprolol in Patients with Acute MI
A recently published retrospective analysis compared the outcomes achieved by administering enalapril alone and in combination with bisoprolol in patients after acute myocardial infarction over a period of 1 year.
News Postoperative Bleeding in Children with Hypofibrinogenemia Induced by Cardiopulmonary Bypass
Patients undergoing cardiac surgery with the use of cardiopulmonary bypass are at risk of up to a 40% reduction in plasma fibrinogen levels, with subsequent risk of perioperative bleeding. Children undergoing surgery for congenital heart defects are even more sensitive to the reduction in fibrinogen. What are the possible solutions, and is any one of them significantly better?
News Estimated Worldwide Prevalence of Population with AAT Deficiency with MZ Alleles
Alpha-1-antitrypsin deficiency (AATD) with the MZ genotype was until recently associated with negligible or low risk for lung and liver tissue damage. However, growing evidence suggests that carriers of MZ alleles are at increased risk of organ damage when exposed to tobacco smoke, polluted air, or hepatotoxic substances. Moreover, according to a global epidemiological study, the prevalence of the MZ genotype is very common, especially among Caucasians in Europe and other continents.
News Register of Patients Treated with Growth Hormone (REPAR): Data Analysis as a Path to Further Optimization of Care
Treatment with recombinant growth hormone (rhGH) is available in the Czech Republic for all children meeting the indication criteria. A network of 10 centers covers the entire country, and all doctors authorized to prescribe growth hormone are united in the Pediatric Growth Hormone Working Group. The Czech national Register of Patients Treated with Growth Hormone (REPAR) has been collecting data on patients treated with rhGH since 2014. The aim of the presented work was to analyze selected data and present the basic demographics of patients included in this database during the first 5 years of its existence.
News Use of Targeted Therapy with Dupilumab in Patients with Allergic Diseases
Interleukins (IL) 4 and 13 play an important role in the pathogenesis of allergic diseases. Their blockade is therefore a suitable strategy for a number of these conditions. This is offered by the new monoclonal antibody dupilumab (Dupixent), which is approved for the treatment of atopic dermatitis, asthma with type 2 inflammation, and chronic rhinosinusitis with nasal polyposis. Studies are ongoing to evaluate its efficacy in other diseases where type 2 inflammation predominates.
News Venetoclax Treatment Strategies in Patients with CLL
One of the new targeted preparations in the treatment of chronic lymphocytic leukemia (CLL) is the Bcl-2 inhibitor venetoclax. Its significant advantage is the potential to achieve deep remission, including undetectable minimal residual disease (MRD). Unlike other targeted drugs, it can be administered for a limited period of time. The following text presents current data from clinical trials and information on the strategy of selecting and sequencing targeted CLL treatment.
News Potential, Benefits and Proper Use of Probiotics in the Treatment of Acute Gastroenteritis in Children
Clinical studies and experiences from clinical practice have shown the benefits of administering probiotics in the treatment of acute gastroenteritis in children. Pediatrician Dr. Natália Szitányi summarizes the possibilities and rationale for their use in this indication.
News Fixed combinations of Enerzair® and Atecura® may improve asthma treatment
The newly approved fixed triple combination Enerzair® and the fixed dual combination Atectura® have demonstrated improvements in lung function and a reduction in exacerbations in previously uncontrolled asthma patients. Administering once daily using the Breezhaler® inhaler along with the possibility of connecting a digital aid aims, among other things, to facilitate usage and proper adherence to the treatment.
News Autonomic Dysfunction in Patients with Transthyretin Amyloidosis
Autonomic nervous system disorders are a common complication of transthyretin amyloidosis. Their frequency, nature, and impact on patients' quality of life were examined in the longitudinal THAOS study.
News Is Adding Fibrinogen Concentrate to Transfusion Therapy for Postpartum Hemorrhage an Effective Approach?
Significant postpartum hemorrhage can be managed with fresh frozen plasma transfusion. However, administering larger volumes is associated with several risks. The authors of the Japanese study below investigated whether fibrinogen concentrate added to fresh frozen plasma transfusions is an effective tool in reducing the need for erythrocyte concentrate and whether it helps prevent complications of intensive transfusion therapy.
News Options for Modifying and Improving the Efficiency of the HJHS Scoring System
The Hemophilia Joint Health Score (HJHS) is a validated tool for assessing joint health in individuals with hemophilia. Can it be modified to be used more effectively in clinical practice?
News Reduction of Enthesitis in Patients with Psoriatic Arthritis Taking Tofacitinib
Inflammation in the area where a tendon, ligament, or joint capsule attaches to the bone occurs in 35–50% of patients with psoriatic arthritis (PsA). Its presence is associated with higher activity of PsA, and its intensity correlates with the degree of joint damage. Patients with enthesitis are generally in worse functional status and report greater fatigue, pain, and decreased productivity. How can treatment with tofacitinib affect this important domain of PsA?