Rozdíly ve fosforylaci Akt v CD4⁺ lymfocytech u patogenní a nepatogenní infekce SIV

English version

Autoři: S. T. Stephenson ¹; V. Bostik ²; P. Bostik ^1,2
Působiště autorů: Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 303 ¹; Faculty of Military Health Sciences, University of Defence, Hradec Králové, Czech Republic ²
Vyšlo v časopise: Epidemiol. Mikrobiol. Imunol. 65, 2016, č. 2, s. 136-144
Kategorie: Původní práce

Souhrn

HIV infekce u lidí a SIV infekce u makaků Rhesus (RM) se vyznačuje zvýšenou apoptózou a aktivací vyvolanou buněčnou smrtí (AICD) CD4 lymfocytů. Avšak některé druhy primátů, jako například afričtí mangabejové (SM), jsou přirozeně infikováni SIV a nerozvine se u nich symptomatické onemocnění. Tato studie ukazuje, že lymfocyty RM infikovaných SIV vykazují sníženou vnitrobuněčnou expresi GSK3beta a současně zvýšenou expresi a fosforylaci (Thr308) kinázy Akt spojenou se stimulací receptorů CD3 a CD28. Tyto rozdíly jsou specificky měřitelné pouze v některých definovaných subpopulacích CD4 lymfocytů. Je to jeden z mála příkladů monofosforylace Akt a tato signalizace může představovat jeden z mechanismů vedoucích k rozdílům v AICD a případně i rezistenci k infekci SIV.

KLÍČOVÁ SLOVA:
T lymfocyty – AIDS – primate – Akt – vnitrobuněčná signalizace

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