Uterine tumors resembling ovarian sex cord tumors (UTROSCT) - popis případu s metastázou do lymfatické uzliny

English version

Autoři: Jirka Mačák ¹; Pavel Dundr ²; Jana Dvořáčková ^1,3; Jaroslav Klát ⁴
Působiště autorů: Department of Pathology, University Hospital and Faculty of Medicine, University of Ostrava, Czech Republic ¹; Department of Pathology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Czech Republic ²; CGB laboratory Inc. Ostrava, Czech Republic ³; Department of Gynecology and Obstetrics, University Hospital Ostrava, Czech Republic ⁴
Vyšlo v časopise: Čes.-slov. Patol., 50, 2014, No. 1, p. 46-49
Kategorie: Původní práce

Souhrn

Popisujeme vzácný nádor dělohy odpovídající ovariálnímu sex cord nádoru (UTROSCT), který má nejistou histogenezi. Ačkoliv je obecně považovaný za benigní, v některých případech metastazuje. V našem případě šlo o 53letou ženu, která přišla do nemocnice s vaginálním krvácením. Klinické vyšetření ukázalo nádor velikosti v průměru 1,5cm, který byl lokalizovaný subendometriálně ve stěně dělohy. Histologicky byl nádor tvořený epiteloidními oválnými buňkami, které tvořily solidní hnízda, trabekuly a pruhy. V imunohistologickém vyšetření bylo přibližně 1 % nádorových buněk výrazně pozitivní s protilátkou proti desminu, kalponinu u 10 % buněk, WT1 u 80 % buněk a Ki-67 bylo pozitivní asi u 5 % nádorových buněk. Ostatní protilátky včetně protilátek proti cytokeratinům byly negativní. Metoda RT-PCR identifikující fúzní transkript JAZF1-JJAZ1 byla negativní. V jedné lymfatické uzlině v oblasti pravé ilické arterie byla zjištěna metastáza UTROSCT. Tento nález můžeme přiřadit k některým dříve popsaným UTROSCT, u kterých se objevily metastázy.

Klíčová slova:
nádor dělohy odpovídající ovariálnímu sex cord tumoru ovaria – UTROSCT – metastáza – lymfatická uzlina

Zdroje

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