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Li-Fraumeni Syndrome –⁠ Indication for Testing and Recommended Surveillance

3. 5. 2023 Source: Genetics

A germline mutation of the TP53 gene, which causes Li-Fraumeni syndrome, results in a congenital predisposition to the occurrence of malignant tumors, such as pediatric malignancies, breast cancer, bone sarcomas, and others. We bring a summary of indications for testing the pathogenic variant of the TP53 gene according to the recommendations of the National Comprehensive Cancer Network (NCCN) and the surveillance program for carriers of this variant according to the consensus of the current recommendations of the European, American, Japanese, and...

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Water Microjet as a Gentler Method of Debridement

Debridement is an integral part of chronic wound treatment. Currently, the most common method is…
3. 5. 2023 Source: Wound Healing
kapky do očí

INFOGRAPHIC: Eye Drops for Dry and Irritated Eyes –⁠ Mechanism of Action and Benefits

2. 5. 2023 Source: Ophthalmologic Diseases
Syndrom Dravetové

Dravet Syndrome –⁠ Get to Know It

Dravet syndrome is a severe myoclonic epilepsy occurring in early childhood. It is classified as a…
2. 5. 2023 Source: Rare Diseases in Neurology
Bolest svalů_muž

When and why to consider the diagnosis of myasthenia gravis in neurological practice, and what treatment options do we currently have?

Myasthenia gravis (MG) is a clinically heterogeneous disease characterized by fluctuating muscle…
2. 5. 2023 Source: Rare Diseases in Neurology
Syndrom suchého oka_žena

Sjögren's Syndrome as a Cause of Dry Eye Syndrome

Primary Sjögren's syndrome represents a complex autoimmune disease primarily affecting glands with…
2. 5. 2023 Source: Ophthalmologic Diseases
plíce 3D model

Infographic and Commentary from Practice: Reasons and Pathways for Patients to Biological Treatment of Asthma

For asthma patients with the most severe forms of the disease to access targeted biological…
28. 4. 2023 Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation
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Subcutaneous pdC1-INH in Patients with Hereditary Angioedema in Real-World Practice

Italian authors published a series of cases of patients with hereditary angioedema caused by C1 inhibitor...
27. 4. 2023 Source: Hereditary Angioedema
screening

Efficacy and Safety of an Activated FXII Inhibitor in Preventing HAE Attacks

Hereditary angioedema (HAE) is a rare, potentially life-threatening inherited disorder characterized...
27. 4. 2023 Source: Hereditary Angioedema
pacient

To what extent does the delay between symptom onset and diagnosis of AATD affect patient survival?

The risk of chronic obstructive pulmonary disease (COPD) is increased, among other things, by a deficiency...
26. 4. 2023 Source: Deficiency of Alpha-1-Antitrypsin
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