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Romosozumab vs. Teriparatide in Sequential Treatment of Osteoporosis in Women with a History of Fracture

14. 11. 2023 Source: Osteoporosis – Trends in Sequential Therapy

The STRUCTURE study observed the effect of romosozumab and teriparatide on bone density in postmenopausal women with osteoporosis transitioning from bisphosphonate treatment over a 12-month period.

How Important is the Time Factor in the Treatment of Heart Failure?

Current guidelines emphasize the importance of early diagnosis and immediate treatment for patients with heart failure (HF). These patients are most vulnerable immediately after the decompensation of…

13. 11. 2023 Source: Heart Failure

Transthyretin Amyloidosis in Patients with Carpal Tunnel Syndrome

Carpal tunnel syndrome is considered a warning sign for cardiac amyloidosis. Amyloid deposits are often found in the tenosynovial material removed during surgery. However, the prevalence of…

10. 11. 2023 Source: Amyloidosis

Inhibition of Mutated KRAS Protein as a New Option for Targeted Treatment of Non-Small Cell Lung Cancer

RAS proteins are molecular switches for several intracellular signaling pathways. Their dysfunction due to mutation leads to the development and progression of malignant diseases such as colon or…

9. 11. 2023 Source: Lung Cancer

MUDr. Tomáš Mašek: In the prevention of hemorrhoids, more use of venopharmaceuticals is needed

While in the past the diagnosis of hemorrhoids was inextricably linked to traditional surgical solutions, today -⁠ thanks to the expansion of the indication for venopharmaceuticals for this condition…

7. 11. 2023 Source: Venous Insufficiency

Balance and Rehabilitation –⁠ Firm on the Ground Even with Multiple Sclerosis

A large portion of patients with multiple sclerosis (MS) suffer from balance disorders. What are the options for non-pharmacological therapy for these issues according to the latest studies?

1. 11. 2023 Source: Multiple Sclerosis

Instead of NSAIDs, consider combining paracetamol with a weak opioid

Chronic non-cancer pain is a problem that primary care physicians encounter on a daily basis. In the following interview with general practitioner MUDr. Michaela Wichová, we discuss how to approach a…

1. 11. 2023 Source: Updates in Pain Treatment

Fixed combination tramadol/paracetamol as an effective and safe option for long-term pain treatment even in polymorbid patients

Combined analgesics were historically recommended exclusively for the treatment of acute or postoperative pain, mainly due to the risk of individual components which, although potentiated their…

1. 11. 2023 Source: Updates in Pain Treatment

Pharmacological Profile of Mavacamten and Key Studies of Its Use in HCM Treatment

A new addition to the treatment options for hypertrophic cardiomyopathy, approved for use in European Union countries in June 2023, is the selective reversible cardiac myosin inhibitor mavacamten.…

1. 11. 2023 Source: Hypertrophic Cardiomyopathy (HCM)

INFOGRAPHIC: Diagnosis and Monitoring of Patients with Hypertrophic Cardiomyopathy –⁠ Current Guidelines

What examinations should be conducted when suspecting hypertrophic cardiomyopathy, a hereditary disease caused by mutations in genes encoding cardiac muscle proteins? What is the subsequent procedure…

1. 11. 2023 Source: Hypertrophic Cardiomyopathy (HCM)

Neutropenia with Thrombocytopenia after Alemtuzumab? −⁠ Case Report

Early neutropenia with thrombocytopenia is not a common side effect of alemtuzumab. However, the patient in the following case report by Italian colleagues was affected. What was the outcome?

1. 11. 2023 Source: Multiple Sclerosis

Safety of aPCC in Real Practice –⁠ Results of the BAHAS Project

What are the experiences with activated prothrombin complex concentrate (aPCC) in controlling bleeding or preventing its recurrence in acquired hemophilia A? The BAHAS project from Spanish real…

31. 10. 2023 Source: Hemophilia

Streptococcus pneumoniae Serotype 3 Continues to Be the Most Frequent Cause of Invasive Pneumococcal Diseases in the Czech Republic

After 2 years influenced by the COVID-19 pandemic, the number of cases of invasive pneumococcal diseases (IPD) has returned to pre-2020 levels. Serotype 3 remains the most frequent cause of IPD for…

26. 10. 2023 Source: Regular Vaccination

Multimodal Treatment of Prostate Cancer in a Patient with Exceptionally Long Overall Survival −⁠ Case Report

A recently published case study by Romanian authors presents a rare instance of long-term survival (15 years) in a patient with locoregional prostate cancer that later metastasized. The case…

26. 10. 2023 Source: Oncological Treatment

Benefit of Short-term Androgen-deprivation Therapy Added to Radiotherapy of Localized Prostate Cancer for Long-term Survival

Androgen-deprivation therapy is associated with several adverse effects that also affect quality of life or increase the risks of serious age-related health problems. An extensive study focused on…

26. 10. 2023 Source: Oncological Treatment

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