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News Satisfaction of Patients Treated with Platinum Derivatives with Antiemetic Therapy
The fixed oral combination of netupitant with palonosetron (NEPA) is used for the prevention of nausea and vomiting induced by cytotoxic chemotherapy. A prospective German study evaluated the benefit of this therapy on the quality of life of patients treated with platinum derivatives.
News Rebound effect after denosumab discontinuation in a patient with lung cancer
The case study of a patient with metastatic lung cancer describes the emergence of vertebral fractures following the discontinuation of denosumab. This antiresorptive treatment was halted prophylactically to reduce the risk of osteonecrosis in connection with a planned dental procedure. Fifteen months after receiving the last dose of denosumab, the patient experienced atraumatic compression fractures of the spine requiring kyphoplasty to alleviate symptoms. Other causes of the fractures were ruled out.
News Limits of Glycated Hemoglobin and the Importance of Other Glycated Proteins
Glycated hemoglobin is a gold standard in the diagnosis and management of diabetes treatment. However, its disadvantages include numerous factors that can cause false increases or decreases in its levels. Therefore, the scientific community is also interested in researching other glycated proteins that could be used in diabetes control. So, what should we keep in mind when collecting glycated hemoglobin?
News Noonan's Syndrome – History and Present
The genetically determined syndrome linking congenital heart defect with a typical facial phenotype is named after Jacqueline Noonan, a pediatric cardiologist who practiced in the second half of the 20th century. She was the first to recognize and describe it. In the following text, we will briefly introduce it and discuss the circumstances of its discovery.
News Angiodysplasia as a Serious Problem in Patients with von Willebrand Disease − Case Study
Bleeding into the gastrointestinal tract can become a very significant cause of morbidity and mortality in patients with von Willebrand disease (vWD). It has been described that gastrointestinal (GI) bleeding associated with angiodysplasia is more common in individuals with vWD compared to other causes. Evidence suggests that von Willebrand factor (vWF) is associated with the regulation of angiogenesis, and its deficiency increases the risk of angiodysplasia. It is also known that this type of bleeding is difficult to treat because it is associated with recurrences. The following case study also very well illustrates and summarizes this issue.
News Protection of Ovarian Function During Breast Cancer Treatment
Women diagnosed with breast cancer of childbearing age are concerned about how to maintain ovarian function even after undergoing chemotherapy. Therefore, a team of doctors from the United Kingdom focused on the gonadotropin-releasing hormone agonist and its ability to protect women from premature menopause after chemotherapy.
News The Importance of Proper Protein and Calorie Intake in Critically Ill Patients – Insights from Recent Comparisons
The issue of nutrition, especially proteins, is a crucial aspect affecting the overall health and prognosis of critically ill patients. Two recent studies published in the journals Critical Care and Journal of Parenteral and Enteral Nutrition focused on nutrient intake.
News Rapid Diagnosis of Depression in Primary Care Settings
Depression is one of the most commonly occurring psychiatric disorders encountered in general practitioners' offices. The general public also very often uses the term “depression” to mean “bad mood.” Thus, a rapid diagnostic tool to identify “real depression” certainly deserves our attention.
News Diabetic Foot Syndrome: An Unpleasant Scare for Diabetics and Their Attending Doctors
Diabetic foot syndrome is a very serious complication of diabetes mellitus (DM). It often leads to destructive tissue damage distal to the ankle. Due to the complex therapy, it is advisable to focus on thorough and meticulous prevention of this complication.
News A Look at Tongue and Its Care from the Perspective of Western and Traditional Chinese Medicine
The tongue is a valuable diagnostic tool used in both Traditional Chinese Medicine (TCM) and Western medicine. While the approaches to tongue care between these two medical systems differ significantly, both recognize the tongue's ability to reflect an individual's overall health. Although these approaches may seem contradictory, with proper application, they can complement each other.
News Mechanism of Action of Venopharmaceuticals and Their Use in the Treatment of Chronic Venous Insufficiency
Venopharmaceuticals are the cornerstone of conservative treatment for chronic venous insufficiency (CVD). Their mechanism of action is complex and not yet fully understood. They act on both micro- and macrocirculation, influence the tone of the venous wall, and their anti-inflammatory action is also significant.
News MUDr. Tomáš Mašek: In the prevention of hemorrhoids, more use of venopharmaceuticals is needed
While in the past the diagnosis of hemorrhoids was inextricably linked to traditional surgical solutions, today - thanks to the expansion of the indication for venopharmaceuticals for this condition - the number of patients who have to undergo these procedures is a minority. We asked coloproctologist MUDr. Tomáš Mašek how the potential of venopharmaceuticals can be utilized in the prevention and treatment of hemorrhoid disease.
News Insufficiently Controlled Epilepsy Reduces Quality and Length of Life
The effects of uncontrolled epilepsy far exceed the moment of a seizure, having a substantial impact on the psychological and physical well-being of patients. These individuals often sustain injuries during seizures, leading to reduced mobility, a higher risk of associated diseases, and premature death.
News Current Approaches to COPD Therapy According to GOLD Recommendations and in the Conditions of Czech Practice
Chronic Obstructive Pulmonary Disease (COPD) represents a significant global cause of morbidity and mortality with a high prevalence that is expected to increase significantly in the coming years. Since it is a preventable and treatable disease, active therapy, which is globally guided by international recommendations based on the GOLD strategy, plays an important role. However, in the following article, we will also place these recommendations in the current context of care for these patients in the Czech Republic.
News Prim. Václava Adámková: People mistakenly believe that there are enough antibiotics and that they will always handle infections
According to the World Health Organization (WHO), by 2050, infections untreatable with antibiotics could become the leading cause of death, surpassing cardiovascular and oncological diseases. Rising antimicrobial resistance was one of the main topics at the VIII Congress of Clinical Microbiology, Infectious Diseases, and Epidemiology (KMINE 2022), held in September in Prague. The topic was also the focus of the expert block ‘ATB stewardship,’ where epidemiologist Petr Smejkal, infectologist Aleš Chrdle, and microbiologist Václava Adámková discussed possible solutions to this global problem. We asked Adámková to summarize insights into the presented issues for us.
News Trazodone as an Effective Medicine in the Therapy of Depression and Insomnia
Trazodone (Trittico®) is a medicine indicated for the treatment of depression, which has also been shown to have a positive effect in treating other associated conditions. In practice, however, the potential of its multimodal effect sometimes remains untapped.
News Side Effects of Metformin: It's Not Just a Nocebo Effect?
If we were to name medications that have the greatest significance from a population standpoint, metformin would certainly be at the top of the list. We have known it for over fifty years and know a lot about it, including its negatives. But is it time to replace it with new drugs? Or is it worth staying with it?
News Memantine in Dementia Therapy – Current Findings and Possible Future Applications
Memantine is an inhibitor of NMDA receptors, which are pathologically activated by excessive concentrations of glutamate in the synaptic cleft in Alzheimer's disease. It is indicated in the treatment of moderate to severe cases of Alzheimer's disease, often in combination with acetylcholinesterase inhibitors. At the experimental level, its administration shows a number of promising effects, including an impact on diabetes associated with the development of neurodegenerative diseases.