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News Combination of Candesartan with ACE Inhibitors in the Treatment of Hypertension and Heart Failure

Although the combination of ACE inhibitors and sartans is not recommended due to the higher incidence of complications, studies also indicate a positive effect of their concurrent administration. The potential use of dual blockade of the renin-angiotensin-aldosterone system (RAAS) is suggested in resistant hypertension, and results have also been described in the treatment of congestive heart failure. What do the recommendations say?

Source: Sartans in the Treatment of Hypertension 25. 5. 2020

Články časopisu Von Willebrand disease

Author of the article: P. Smejkal, M. Matýšková, M. Penka Source: Vnitřní lékařství | 3/2008 9. 3. 2008

News Benefit of Maintenance Therapy with Olaparib in Newly Diagnosed Advanced Ovarian Cancer

The SOLO-1 study evaluated whether the use of the PARP inhibitor olaparib in the maintenance treatment of patients with newly diagnosed advanced ovarian, fallopian tube, or peritoneal cancer with BRCA 1/2 mutation leads to an improved prognosis for these patients.

Source: Ovarian and Breast Cancer 17. 3. 2020

News Effectiveness of Dietary Intervention in Irritable Bowel Syndrome –⁠ Results of a Network Meta-Analysis

A low FODMAP diet is often recommended to alleviate symptoms of irritable bowel syndrome (IBS). Although several randomized studies have been conducted to assess the effectiveness of this diet, a systematic evaluation has yet to be available, and individual studies have used various control interventions. Therefore, an international team of researchers decided to prepare a systematic literature review with a network analysis, recently published in the journal Gut.

Source: Irritable Bowel Syndrome 12. 10. 2022

News Do Asthma Bronchiale and COPD Represent a Risk Factor for Severe COVID-19 and Death?

It is well known that patients with bronchial asthma and chronic obstructive pulmonary disease (COPD) have a higher risk of severe course of common viral respiratory diseases. A study by Belgian authors involving several hundred individuals evaluated the risk of ICU admission and death due to COVID-19 in patients with asthma and COPD compared to patients without these conditions. The other goal was to determine whether these risks are influenced by inhalation corticosteroid therapy or not.

Source: Treatment of Asthma and COPD 8. 11. 2021

News Pitfalls of Levothyroxine Replacement Therapy

Hypothyroidism (reduced function of the thyroid gland) affects approximately 1-2% of the population. Its prevalence increases with age and it is more common in women. Synthetic thyroid hormone levothyroxine is used to treat hypothyroidism. It is a widely prescribed medication available in tablets of various strengths.

Source: Thyroid Disorders 8. 3. 2021

News CASE STUDY: Key Benefits of GLP-1RA in Diabetes Therapy in the Office of a General Practitioner

Modern therapy using glucagon-like peptide-1 receptor agonists (GLP-1RA) offers diabetics highly effective management of their primary condition as well as several other advantages: it reduces the risk of hypoglycemia, aids in weight loss, and has a positive impact on the heart and blood vessels, including increasing the chances of preventing and delaying the progression of micro and macrovascular complications. Early initiation of this treatment not only significantly improves diabetes control but also helps in preventing or delaying the development of atherosclerosis and cardiometabolic syndrome.

Source: Modern Treatment of Diabetes with GLP-1 Analogues 16. 5. 2024

News Dual therapy improves not only lung function but also quality of life in COPD patients

Chronic obstructive pulmonary disease (COPD) reduces the quality of life of patients and is one of the main causes of morbidity and mortality. According to international recommendations, the initial pharmacotherapy is recommended as monotherapy with LAMA (long-acting muscarinic antagonists) or LABA (long-acting beta-agonists), or their combination. A pooled analysis of 4 studies compared the early addition of LABA to LAMA in patients with moderate to severe COPD.

Source: COPD 15. 4. 2021

Články časopisu Some Controversies in Gynecology and Obstetrics

Author of the article: M. Velemínský ml., M. Velemínský st. Source: Česko-slovenská pediatrie | 10/2010 9. 10. 2010

News Obinutuzumab and Early Progression of Patients with Previously Untreated Follicular Lymphoma −⁠ Analysis of Data from the GALLIUM Study

The GALLIUM study demonstrated longer progression-free survival (PFS) in patients with previously untreated follicular lymphoma (FL) treated with obinutuzumab compared to rituximab. The aim of the exploratory data analysis was to evaluate the impact of obinutuzumab on the incidence of early disease progression and the relationship between early progression and overall survival (OS) of the patients.

Source: Non-Hodgkin Lymphomas and CLL 23. 4. 2020

News AAD 2023: Efficacy of Bimekizumab in the Treatment of Hidradenitis Suppurativa

At the latest annual congress of the American Academy of Dermatology (AAD), held March 17-22, 2023 in New Orleans, the results of the phase III BE HEARD I and II studies were presented among late-breaking presentations. The studies demonstrate the safety and high efficacy of bimekizumab in the treatment of adults with moderate to severe hidradenitis suppurativa (HS).

Source: Psoriasis 7. 4. 2023

News What to add to amlodipine when it alone is not enough for hypertension?

Treating hypertension is a daily task for not only general practitioners and cardiologists. Polish doctors evaluated the effect of adding bisoprolol on the blood pressure of patients with inadequately controlled hypertension on amlodipine monotherapy in a placebo-controlled AMCOR study.

Source: Cardiovascular Continuum 18. 3. 2024

News Clinical and Microbiological Effect of L. reuteri in the Treatment of Chronic Periodontitis

The Journal of Clinical Periodontology published the results of a study evaluating the effect of the probiotic bacterial strain Lactobacillus reuteri as an adjunctive treatment for chronic periodontitis.

Source: GI, colic and microbiome 6. 4. 2022

News How and with What the National Registry of Primary Immunodeficiencies Benefits Specialists and Patients

Primary immunodeficiencies constitute a very heterogeneous group of congenital diseases. They affect both specific and nonspecific immunity and are classified accordingly. The care for patients with antibody production disorders and hereditary angioedema (HAE) is economically the most demanding and relatively specific. Can a specialized registry help improve this care?

Source: Hereditary Angioedema 3. 1. 2022

News Programmed Cell Death as a Therapeutic Target in Chronic Lymphocytic Leukemia

One of the key steps in malignant transformation is the disruption of apoptosis. Tumor cells exploit a variety of mechanisms that allow them to evade programmed cell death. Among the drugs targeting apoptosis pathway regulators is venetoclax, a Bcl-2 protein inhibitor used in the treatment of chronic lymphocytic leukemia (CLL). Since August 2021, venetoclax in combination with obinutuzumab can newly be used as a reimbursed therapy for previously untreated patients with CLL who are not suitable for fludarabine administration.

Source: Chronic Lymphocytic Leukemia 10. 8. 2021