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News Is the Quality of Life for Patients with Atrial Fibrillation and Heart Failure Comparable When Treated with Bisoprolol and Digoxin?
The British RATE-AF study, published in December 2020 in the JAMA journal, compared the impact on improving the quality of life in patients with permanent atrial fibrillation (AF) and symptoms of heart failure when administering bisoprolol and low-dose digoxin.
News Expanded Vaccination Option Against Pneumococci Thanks to 15valent Vaccine
Our arsenal for preventing pneumococcal diseases has been expanded with a 15-valent conjugate vaccine that includes important serotypes causing invasive pneumococcal diseases (IPD). The following text briefly summarizes basic information not only about IPD, their prevention, diagnosis, and treatment, but especially about the management of vaccination with the 15-valent vaccine in practice.
News Characteristics of Chronic Wounds Related to Itching During Healing
Itching of wounds during healing is associated with larger wound size, more extensive tissue swelling, and the presence of granulation and necrotic tissue at the base. This was shown by an observational descriptive American study with 200 patients.
News Case of Heparin Allergy and Preventive Administration of Fondaparinux in Pregnancy – Case Study
The presented case study discusses a complicated case of a 40-year-old woman with essential thrombocythemia (ET), a history of intrauterine fetal death, and recurrent pulmonary embolism (PE). The patient developed an allergic reaction to low-molecular-weight heparin (LMWH) and was successfully managed with fondaparinux during pregnancy.
News Asthma is not a risk factor for a severe course of COVID-19
According to the statement of the Czech Initiative for Asthma from April 2020, the disease COVID-19 caused by the new type of coronavirus does not pose significantly greater danger for people with asthma than for the general population. It is, however, necessary to adhere to the prescribed treatment and keep asthma under control. The Journal of Allergy and Clinical Immunology provides an explanation for this surprising phenomenon. It is the reduced expression of ACE2 receptors in people with asthma and allergies, as shown by a new study involving three cohorts of pediatric and adult patients. The SARS-CoV-2 virus uses ACE2 receptors to enter the host cell.
News Residual Pulmonary Hypertension After Endarterectomy: How Common Is It?
Pulmonary endarterectomy is the only potentially curative option in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH). What are its outcomes and in what percentage of cases does it lead to complete cure? A meta-analysis, significantly contributed to by Czech experts, was dedicated to the improvement of signs and symptoms of CTEPH after performing endarterectomy.
News Romosozumab vs. Teriparatide in Sequential Treatment of Osteoporosis in Women with a History of Fracture
The STRUCTURE study observed the effect of romosozumab and teriparatide on bone density in postmenopausal women with osteoporosis transitioning from bisphosphonate treatment over a 12-month period.
News Efficacy and Safety of Single-Application Hyaluronic Acid in Osteoarthritis Therapy
Causal therapy for osteoarthritis does not yet exist. Patients suffering from progressive joint disease are thus dependent on symptomatic medications that alleviate symptoms and partially slow the progression of osteoarthritis. An essential role in therapy is played by viscosupplementation in the form of intra-articular application of hyaluronic acid (HA). Currently, 3rd generation preparations intended for single application are preferred due to their efficiency and safety.
News Telmisartan, amlodipine, and chlorthalidone in a low-dose fixed triple combination – better control of target blood pressure values?
The secondary analysis of the TRIUMPH study, recently published in JAMA Cardiology, is likely the first published assessment of time spent in the target blood pressure (BP) range during antihypertensive treatment. This parameter was assessed in patients with moderate hypertension using a low-dose triple combination of antihypertensives (telmisartan 20 mg, amlodipine 2.5 mg, and chlorthalidone 12.5 mg) compared to usual care.
News Kidney Carcinoma – Key Facts About the Disease With the Highest Incidence Worldwide in the Czech Republic
The incidence of renal carcinoma is increasing every year. About a quarter of the cases are still diagnosed in the metastatic stage, yet early treatment can save lives. Below, we briefly summarize data on the incidence, etiology, and risk factors of this malignant disease based on a literature review from 1945–2015. These findings may be significant for prevention and screening in high-risk individuals.
News Continuous Infusion of Tiapride in the Treatment of Hyperactive Delirium – Case Study
Spanish authors recently published a case study of a young man with pharmacologically unmanageable agitation delirium following multiple injuries from a traffic accident, which resolved within 3 days with continuous infusion of tiapride.
News Metamizole in perioperative treatment in children under 14 years – results of a questionnaire survey from practice
A recent survey among German-speaking physicians evaluated the use of non-opioid analgesics in perioperative care in children under 14 years. It focused on the use of metamizole and the monitoring of possible agranulocytosis associated with this drug.
News Oral Azacitidine Prolongs Survival of AML Patients Regardless of Measurable Residual Disease
Intensive chemotherapy for patients newly diagnosed with acute myeloid leukemia (AML) often achieves high remission rates, although these remissions are often only temporary. Consolidation therapy with azacitidine (AZA) extends post-remission survival and disease-free intervals.
News Effect of Zolpidem on the Quality of Overnight Sleep in Terms of Episodic Memory Formation
Zolpidem is a non-benzodiazepine hypnotic used for the short-term treatment of insomnia in adults. Previous studies have shown that this gamma-aminobutyric acid (GABA-A) agonist stimulates the occurrence of sleep spindles during short daytime sleep, thereby enhancing episodic memory. A recently published study focused on the effect of zolpidem on memory after overnight sleep.
News Inosine pranobex in the treatment of influenza and other respiratory infections of viral etiology
The antiviral inosine pranobex is a clinically proven immunomodulator for the treatment of patients from 1 year of age, indicated for a wide range of diseases with manifestations of immune insufficiency and viral infections. It acts by a direct antiviral effect, modulates the immune system, and also finds application in the treatment of acute viral respiratory diseases, such as influenza and other seasonal viral infections.
News Transthyretin – More Than a Thyroxine Transporter
Transthyretin (TTR) is an extracellular protein whose main role is to transport thyroxine and retinol in the body and brain. TTR tends to form amyloid deposits, which can lead to systemic disease known as TTR amyloidosis. Recently, it has been shown that this protein has a much wider spectrum of activities in the organism than previously thought.
News Dravet Syndrome – Get to Know It
Dravet syndrome is a severe myoclonic epilepsy occurring in early childhood. It is classified as a rare progressive epileptic encephalopathy, characterized by generalized or lateralized clonic seizures often prolonged and linked to febrile infections. Other forms of seizures later appear, leading to deterioration in psychomotor development and the onset of mental retardation. Early diagnosis and treatment are desirable.
News Detection of ceftazidime/avibactam-resistant Enterobacteriaceae strains using a new rapid test
Ceftazidime/avibactam (CZA) is a relatively new antibiotic with very good efficacy against carbapenem-resistant Enterobacteriaceae. Unfortunately, strains resistant to this antimicrobial treatment are now beginning to emerge. The authors of the presented study developed and tested a new laboratory test for the rapid and accurate detection of these multidrug-resistant Enterobacteriaceae.
News Dyslipidemia in the General Practitioner's Office – Featuring LDL Cholesterol
Monitoring LDL cholesterol (LDL-c) levels is crucial in diagnosing hypercholesterolemia as it is directly linked to increased cardiovascular risk. What other tests should be performed upon detecting hypercholesterolemia and which medications can effectively help reduce LDL-c levels?
News Monocyte Distribution Width as a New Indicator of Sepsis in High-Risk Patients
Most septic patients are first encountered in the emergency department, where sepsis detection is often delayed, partly due to a lack of effective biomarkers. The study presented below evaluated the diagnostic accuracy of monocyte distribution width in peripheral blood alone and in combination with white blood cell count evaluation for early sepsis detection.
News Monocyte Distribution Width Indicates Sepsis Regardless of Sepsis Etiology
Patients in intensive care units represent a high-risk population for the development of sepsis, which is one of the primary causes of mortality in these settings. The aim of the recently published study was to evaluate the diagnostic accuracy and prognostic properties of the monocyte distribution width parameter in septic patients.
News Urinary Incontinence in Old Age as the Most Frequent Medical Problem
In patients over 65 years of age, incontinence occurs more frequently than cancer or cardiovascular diseases. Urine leakage significantly reduces the quality of life for seniors, worsens their overall health, and isolates them from society. Therefore, doctors should participate in destigmatizing this problem and actively offer their help to seniors and their family members.
News Use of Tiapride in the Treatment of Behavioral Disorders in Geriatric Patients
Hand in hand with the increasing number of people reaching an older age, there is also a rise in the occurrence of dementia. It affects the lives of patients and their families in many ways. A significant problem can be behavioral disorder, which needs to be treated adequately and promptly to prevent issues such as injuries.
News Idiopathic Pulmonary Fibrosis from the Perspective of an Outpatient Pulmonologist
Idiopathic pulmonary fibrosis represents a rare disease of lung tissue with an as-yet-unexplained etiology. In the framework of differential diagnosis, it is necessary to consider the disease, as early diagnosis combined with the deployment of antifibrotic therapy extends patients' lives.