Asociace polymorfizmu NAD (P) H chininové oxidoreduktázy 1 rs1800566 s karcinomem močového měchýře a prostaty – systematický přehled a metaanalýza

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Autoři: Mehdi Abedinzadeh ¹; Mansour Moghimi ²; Alireza Seyed Dastgheib ³; Hossein Maleki ¹; E. Salehi ⁴; Z. Mohammad ⁵; Hossein Mohammad Jarahzadeh ⁶; Hossein Neamatzadeh ^7,8
Působiště autorů: Department of Urology, Shahid Sadoughi University of Medical Sciences, Shahid Rahnamoun Hospital, Yazd, Iran ¹; Department of Pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ²; Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran ³; Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran ⁴; Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ⁵; Department of Anesthesiology and Critical Care, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ⁶; Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ⁷; Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran ⁸
Vyšlo v časopise: Klin Onkol 2020; 33(2): 92-100
Kategorie: review
doi: https://doi.org/10.14735/amko202092

Souhrn

Východiska: Bylo provedeno několik studií s cílem zkoumání asociace polymorfizmu NAD (P) H chinin oxidoreduktázy 1 (NQO1) rs1800566 s rizikem karcinomu močového měchýře a prostaty, ale byly předloženy nekonzistentní výsledky. Proto jsme provedli metaanalýzu, abychom poskytli komplexní údaje o asociaci polymorfizmu NQO1 rs1800566 s karcinomem močového měchýře a prostaty.

Metody: Příslušné studie byly identifikovány v databázích PubMed, Google Scholar, EMBASE a China National Knowledge Infrastructure před 1. červnem 2019.

Výsledky: Bylo vybráno celkem 22 případových kontrolních studií zahrnujících 15 studií karcinomu močového měchýře se 4 413 případy a 4 275 kontrolami a 7 studií karcinomu prostaty s 762 případy a 1 813 kontrolami. Souhrnná data ukázala, že polymorfizmus NQO1 rs1800566 byl významně asociován se zvýšeným rizikem karcinomu močového měchýře (T vs. C: OR 1,300; 95% CI 1,112–1,518; p = 0,001; TT vs. CC: OR 1,415; 95% CI 1,084–1,847; p = 0,011; TC vs. CC: OR 1,389; 95% CI 1,111–1,738; p = 0,004; TT + TC vs. CC: OR 1,428; 95% CI 1,145–1,782; p = 0,002) a karcinomu prostaty (TC vs. CC: OR 1,276; 95% CI 1,047–1,555; p = 0,016; TT + TC vs. CC: OR 1,268; 95% CI 1,050–1,532; p = 0,014). Analýza stratifikovaná podle etnicity odhalila zvýšené riziko karcinomu močového měchýře u Kavkazanů a karcinomu prostaty u Asiatů.

Závěr: Tato metaanalýza naznačuje, že polymorfizmus NQO1 rs1800566 byl významně spojen se zvýšeným rizikem karcinomu močového měchýře a prostaty.

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Klíčová slova:

karcinom močového měchýře – karcinom prostaty – gen NQO1 – polymorfizmus – metaanalýza

Zdroje

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