Th17 lymfocyty a interleukin-17A v průběhu těžké komunitní pneumonie, srovnání s etiologií a výsledkem

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Autoři: M. Moravec ; T. Nejtek ; M. Ibrahimová ; R. Zazula ; M. Müller
Působiště autorů: Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic ¹; Department of Anesthesiology and Intensive Care, First Faculty of Medicine, Charles University and Thomayer University, Hospital, Prague, Czech Republic ²
Vyšlo v časopise: Epidemiol. Mikrobiol. Imunol. 73, 2024, č. 3, s. 131-139
Kategorie: Původní práce
doi: https://doi.org/10.61568/emi/11-6352/20240726/138064

Souhrn

Cíl: Observační studie pacientů diagnostikovaných s těžkou komunitní pneumonií (sCAP) sledovala hladiny interleukinu-17A a počtu T helper 17 (Th17) lymfocytů v periferní cirkulaci a tekutině z bronchoalveolární laváže (BAL) v časném průběhu komunitní pneumonie různé etiologie a porovnala je s charakteristikami pacientů a klinickým výsledkem.

Materiál a metody: Kohorta 74 pacientů s těžkou komunitní pneumonií byla analyzována s identifikací jednotlivých původců pneumonie. Podle etiologie byli pacienti rozděleni do tří skupin: bakteriální, virové a smíšené etiologie. Počet Th17 lymfocytů a koncentrace IL-17A byly měřeny s využitím průtokové cytometrie a metody ELISA v periferní krvi a tekutině z BAL.

Data byla porovnána podle etiologie sCAP a statistickou analýzou stanovena jejich korelace s 30a 90denní mortalitou. Výsledky: Statistická korelace mezi počtem Th17 lymfocytů a koncentrací IL-17A v krvi ani v tekutině z BAL s 30a 90denní mortalitou nebyla prokázána. Nicméně, zvýšený počet Th17 lymfocytů v periferní cirkulaci, nikoli však v tekutině z BAL, v časném průběhu sCAP koreloval se zvýšeným relativním rizikem úmrtí. Dalšími faktory zvyšujícími relativní riziko smrti byl věk a mužské pohlaví.

Závěr: Hladiny Th17 a IL-17A v systémové cirkulaci v časném průběhu sCAP (v prvních 7 dnech od diagnózy) mohou korelovat s tíží a mortalitou sCAP.

Klíčová slova:

těžká komunitní pneumonie (sCAP) – Th17 lymfocyty – interleukin-17A

Zdroje

REMAP-CAP Trial Internet. 2024 cited 2024 May 13. Available at www: https://www.remapcap.org.
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