Use of PRP for treatment of tibia fracture with delayed consolidation: case report

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Autoři: Maslennikov Serhii; Kozhemyaka Maxim
Působiště autorů: Traumatology and Orthopedics of Zaporizhzhya State Medical University, Ukraine
Vyšlo v časopise: Clinical Osteology 2022; 27(4): 147-150
Kategorie: Kazuistiky

Souhrn

Delayed consolidation of fractures is one of the most frequent complications in orthopedic practice. With the development of new methods of regenerative medicine, including Platelet-Rich Plasma (PRP), new possibilities for conservative treatment of this problem have emerged. This article presents a clinical case of conservative treatment of delayed consolidation of a tibial fracture using local PRP injections. In the fracture space, PRP releases various inducers of tissue growth and acting on receptors indirectly causing a chemotactic effect, mobilizes the body’s own resources and create conditions for angiogenesis and trophism of injured segment. All PRP factors affect the vascular and cellular components, without which bone restoration is not possible. In the patient with delayed consolidation after PRP treatment, progress in clinical and radiological dynamics with complete healing within 1 year is noted. A positive clinical result provides a basis for further study and implementation in practice.

Zdroje

1. Zura R, Mehta S, Della Rocca GJ et al. Biological Risk Factors for Nonunion of Bone Fracture. JBJS Reviews 2016; 4(1):1 e.5: 72–76. Available from DOI: <http://doi: 10.2106/JBJS.RVW.O.00008>.

2. Nicholson JA, Makaram N, Simpson A et al. Fracture nonunion in long bones: A literature review of risk factors and surgical management. Injury 2021; 52 (Suppl 2): S3-S11. Available from DOI: <http://doi:10.1016/j.injury.2020.11.029>.

3. Lynch JR, Taitsman LA, Barei DP et al. Femoral nonunion: risk factors and treatment options. J Am Acad Orthop Surg 2008; 16(2): 88–97. Available from DOI: <http://doi: 10.5435/00124635–200802000–00006>.

4. Rupp M, Biehl C, Budak M et al. Diaphyseal long bone nonunions – types, aetiology, economics, and treatment recommendations. Int Orthop 2018; 42(2): 247–258. Available from DOI: <http://doi: 10.1007/s00264–017–3734–5>.

5. Roffi A, Filardo G, Kon E et al. Does PRP enhance bone integration with grafts, graft substitutes, or implants? A systematic review. BMC Musculoskelet Disord 2013; 14: 330. Available from DOI: <http://doi:10.1186/1471–2474–14–330>.

6. Marx RE, Armentano L, Olavarria A et al. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent 2001; 10(4): 225–228. Available from DOI: <http://doi: 10.11607/jomi.te04>.

7. Sun Y, Feng Y, Zhang CQ et al. The regenerative effect of platelet-rich plasma on healing in large osteochondral defects. Int Orthop 2010; 3 4(4): 5 89–597. A vailable from DOI: < http://doi: 1 0.1007/s00264–009–0793–2>.

8. Ghaffarpasand F, Shahrezaei M, Dehghankhalili M. Effects of Platelet Rich Plasma on Healing Rate of Long Bone Non-union Fractures: A Randomized Double-Blind Placebo Controlled Clinical Trial. Bull Emerg Trauma 2016; 4(3): 134–140.

9. Anitua E, Andia I, Ardanza B et al. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb and Haemost 2004; 91(1): 4–15. Available from DOI: <http://doi: 10.1160/TH03–07–0440>.

10. Milano G, Deriu L, Sanna Passino E et al. Repeated platelet concentrate injections enhance reparative response of microfractures in the treatment of chondral defects of the knee: an experimental study in an animal model. Arthroscopy 2012; 28(5): 688–701. Available from DOI: <http://doi: 10.1016/j.arthro.2011.09.016>.

11. Filardo G, Kon E, Della Villa S et al. Use of platelet-rich plasma for the treatment of refractory jumper's knee. Int Orthop 2009; 34(6): 909–915. Available from DOI: <http://doi: 10.1007/s00264–009–0845–7>.

12. Dallari D, Savarino L, Stagni C et al. Enhanced tibial osteotomy healing with use of bone grafts supplemented with platelet gel or platelet gel and bone marrow stromal cells. J Bone Joint Surg Am 2007; 89(11): 2413–2420. Available from DOI: <http://doi: 10.2106/JBJS.F.01026>.

Štítky

Biochemie Dětská gynekologie Dětská radiologie Dětská revmatologie Endokrinologie Gynekologie a porodnictví Interní lékařství Ortopedie Praktické lékařství pro dospělé Radiodiagnostika Rehabilitační a fyzikální medicína Revmatologie Traumatologie Osteologie

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