Treatment of Epileptic Syndromes in Children

Česká verze

Authors: V. Komárek
Authors place of work: Klinika dětské neurologie a Centrum pro epilepsie 2. LF UK a FN v Motole, Praha
Published in the journal: Cesk Slov Neurol N 2007; 70/103(5): 473-485
Category: Minimonografie

Poděkování: autor děkuje MUDr. Katalin Štěrbové a MUDr. Pavlu Krškovi, Ph.D. za pomoc s obrazovou dokumentací.

Summary

The paper provides an overview of the full spectrum of age-related epileptic syndromes in children. The author describes treatment strategies based on semiologic, syndromologic and, in some cases, ethiopathogenetic diagnoses. Traditional pharmacotherapeutic management as well as the potential for epilepsy surgery are described. The paper emphasizes the different approaches to treatment of benign forms and risks related to delayed therapy of catastrophic syndromes. Special attention is paid to paradoxical effects of treatment with unsuitable antiepileptics that have the potential to significantly worsen the progression of some of the age-related syndromes.

Key words:
age-related epileptic syndromes – epileptic encephalopathies – treatment of epileptic syndromes – idiopatic generalized epilepsies – prognosis

Zdroje

1. Menkes JH, Sarnat HB, Maria BL. Child Neurology 7th ed. Philadelphia: Lippincott Williams& Wilkins 2006: 857-942.

2. Roger J, Bureau M, Dravet Ch,Genton P, Tassinari CA, Wolf P. Epileptic syndromes in infancy, chidlhood and adolescence 3rd ed. Eastkeight UK: John Libbey&Co Ltd. 2002.

3. Komárek V. Epileptické záchvaty a syndromy. Praha: Galén 1997.

4. Klein P, van Passel-Clark LMA, Pezzullo JC. Onset of epilepsy at the time of menarche. Neurology 2003; 60: 495-497.

5. Panayitopoulos CP. The Epilepsies: Seizures, Syndromes and Management. Bladon Medical Publishing 2004.

6. Dolanský J. Současná epileptologie. Praha: Triton 2000.

7. Rennie JM. Neonatal seizures and their treatment. Curr Op Neurol 2003: 16; 177-181.

8 Ohtahara S, Yamatogi Y. Epileptic encephalopathies in early infancy with suppression burst. J Clin Neurophysiol 2003; 20(6): 398-407.

9. Kršek P, Tichý M, Zámečník J, Paulas L, Faladová L, Jiruška P et al. Life.saving epilepsy surgery for status epilepticus caused by cortical dysplasia. Epileptic Disorders 2002, 4(3): 203-208.

10. Kršek P, Sebroňová V, Procházka T, Maulisová A, Komárek V. Successful treatment of Ohtahara syndrome with chloral hydrate. Pediatric Neurology 2002; 27(5): 388-391.

11. Sýkora P. Liečba epileptických syndromov v detskom veku s nepriaznivou prognózou. Neurol pro praxi 2007; 2: 87-90.

12. Dalla Bernardina B, Dulac O, Fejerman N, Dravet C, Capovilla G, Bondavalli S et al. Early myoclonic epileptic encephalopathy (EMEE). Eur J Pediatr 1983; 140: 248-252.

13. Offringa M. Seizures associated with fever in childhood. Rotterdam: Mosby 1995.

14. Riikonen R. A long-term follow-up study of 214 children with the syndrome of infantile spasms. Neuropediatrics 1982; 13: 14-23.

15. Mackey MT, Weiss SK, Adams-Webber MLS, Ashwal S, Stephens D, Ballaban-Gill K et al. Practice parameter: medical treatment of infantile spasms. Report of the American Academy of Neurology and the Child Neurology Society. Neurology 2004; 62: 1668-1681.

16. Hancock E, Osborne JP. Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: literature review. J Child Neurol 1999; 14: 71-74.

17. Uthman BM, Reid SA, Wilder BJ, Andriola MR, Beydoun AA. Outcome for West syndrome following surgical treatment. Epilepsia 1991; 32: 668-671.

18. Chiron C, Marchand MC, Tran A, Rey E, d´Athis P, Vincent J et al. Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group. Lancet 2000; 356(9242): 1638-1642.

19. Glauser TA, Levisohn PM, Ritter F, Sachdeo RC. Topiramate in Lennox-Gastaut syndrome:open-label treatment of patients completing a randomized controlled trial. Epilepsia 2000; 41(Suppl 1): S86-90.

20. Trevathan E, Motte J, Arvidsson J, Manasco P, Mullens L. Safety and tolerability of adjunctive Lamictal for the treatment of the Lennox-Gastaut syndrome: results of multinational, double-blind, placebo-controlled trial. Epilepsia 1996; 37: 202(Abstract).

21. Pearl PL, Carrazana EJ, Holmes GL. The Landau-Kleffner syndrome. Epilepsy Curr 2001; 1(2): 39-45.

22. Patry G, Laygoubi S, Tassinari CA. Subclinical electrical status epilepticus induced by sleep in children. Arch Neurol 1971; 24: 242-252.

23. Inutsuka M, Kobayashi K, Oka M, Hattori J, Ohtsuka Y. Treatment of epilepsy with electrical status epilepticus during slow sleep and its related disorders. Brain Dev 2005; 24: l-6.

24. Kramer U, Watemberg N, Zelnik N, Shahar E, Lerman-Sagie T, Goldberg-Stern H et al. Efficacy of corticosteroid therapy in treating epileptic encephalopathies and refractory epilepsies other than West syndrome. J Pediatr Neurol 2006; 4(3): 147-153.

25. De Negri M, Baglietto MG, Battaglia FM, Gaggero R, Pessagno A, Recanati L. Treatment of electrical status epilepticus by short diazepam (DZP) cycles after DZP rectal bolus test. Brain Dev 1995; 17: 330-333.

26. Pardo CA, Vining EPG, Guo L, Skolasky RL, Carson BS, Freeman JM. The Pathology of Rasmussen Syndrome: Stages of Cortical Involvement and Neuropathological Studies in 45 Hemispherectomies. Epilepsia 2004; 45: 516–526.

27. Holmes GL. Clinical Spectrum of Benign Focal Epilepsies of Childhood. Epilepsia 2000; 41(8): 1051-1052.

28. Chahine LM, Mikati MA. Benign partial localization-related epilepsies Part II. Syndromes in childhood. Epileptic Disorders 2006; 8: 243- 258.

29. Komárek V. Léčba věkově vázaných epileptických syndromů s příznivější prognózou. Neurol pro praxi 2007; 2: 87-90.

30. Rating D, Wolf Ch, Bast T. Sulthiame as monotherapy in children with benign childhood epilepsy with centrotemporal spikes: a 6-month randomized, double-blind, placebo-controlled study. Epilepsia 2000; 41: 1284-1288.

31. Hahn A. Atypical benign partial epilepsy/pseudo-Lennox syndrome. Epileptic Disord 2000; 2 (Suppl 1): S11-17.

32. Neubauer BA, Halm A, Doose H, Tuxhorn I. Myoclonic-astatic epilepsy of early childhood-definition, course, nosography, and genetics. Adv Neurol 2005; 95:147-155.

33. Weber P. Tillmann B. Myoclonic-astatic epilepsy in early childhood: review of clinical signs, EEG features, etiology, and therapy. Klin Paediatr 2002; 214(5): 279-284.

34. Oguni H, Tanaka T. Treatment and Long-Term Prognosis of Myoclonie – Astatic Epilepsy of Early Childhood. Neuropediatrics 2002; 33(3): 122-132.

35. Khosravani H, Zamponi GW. Voltage-Gated Calcium Channels and Idiopathic Generalized Epilepsies. Physiol Rev 2006; 86(3): 941–966.

36. Perucca E. The Management of Refractory Idiopathic Epilepsies. Epilepsia 2001; 42: 31–35.

37. Labate A. Levetiracetam in patients with generalised epilepsy and myoclonic seizures: an open label study. Seizure 2006; 15: 214-218.

38. Sazgar B. Aggravation of Epilepsy By Antiepileptic Drug. Pediatric Neurology 2005; 33(4): 227-234.