Štúdium lokálnych anestetík: Časť 201*
Stanovenie kritickej micelovej koncentrácie pentakaíniumchloridu pomocou merania UV absorpcie pyrénu v metanolovom prostredí

English version

Autoři: Jana Gališinová • Fils Andriamainty • Ivan Malík • Jozef Čižmárik • Ľubica Sichrovská
Působiště autorů: Comenius University in Bratislava, Faculty of Pharmacy Department of Pharmaceutical Chemistry, Bratislava
Vyšlo v časopise: Čes. slov. Farm., 2013; 62, 132-135
Kategorie: Původní práce

Souhrn

Proces tvorby miciel lokálneho anestetika pentakaínium-chloridu (K 1902) v dvoch rôznych koncentráciách metanolu sa študoval pomocou merania absorbancie pyrénu v roztoku surfaktantu v UV-VIS oblasti spektra. Závislosť absorbancie všetkých hlavných píkov pyrénu od koncentrácie surfaktantu má charakteristický sigmoidálny priebeh. Hodnoty cmc študovaných systémov sa získali fitovaním Sigmoidálnou-Boltzmannovou funkciou. Študoval sa vplyv metanolu na hodnoty kritickej micelovej koncentrácie. Zistilo sa, že kritická micelová koncentrácia stúpa so vzrastajúcou koncentráciou alkoholu v roztoku.

Kľúčové slová:
lokálne anestetikum • pentakaínium-chlorid • kritická micelová koncentrácia • pyrénová absorpcia • Sigmoidálna-Boltzmannova rovnica • metanol

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