Výskyt a charakterizácia protilátok protistafylokokovým enterotoxínomu gynekologických pacientiek

The Occurrence and Describing of Antibodies againstStaphylococcal Enterotoxins in Gynaecological Patients

Objective:
To control the occurrence of the antibodies against Staphylococcal type A and type Benterotoxin in gynaecological patients and in selected patients to determine the thermodynamicparametres of antibodies against Staphylococcal enterotoxins in their blood samples.Design: Retrospective clinical study.Setting: 2nd Department of Obstetrics and Gynaecology, P. J. Šafárik University Košice, Slovak Republic;Research Institute of Veterinary Medicine, Košice, Slovak Republic; Department of Microbiologyand Immunology, University of Veterinary Medicine, Košice, Slovak Republic; Department ofFood Microbiology and Toxicology, Food Research Institute, University of Wisconsin,Madison, USA.Methods: The occurrence of antibodies against Staphylococcal type A and type B enterotoxin wasdetermined in 68 patients hospitalized in Department of Obstetrics and Gynecology in Košice.Results: The occurence of antibodies against Staphylococcal enterotoxins was determined byradioimmunoassay (RIA) in blood samples of 45 (66 %) patients. The antibodies against Staphylococcaltype A enterotoxin were determined in 36 (53 %) patients and the antibodies against Staphylococcaltype B enterotoxin were determined in 9 (13 %) patients. The antibodies against bothtype A and type B enterotoxins were determined simultaneously in blood samples of 10 % of allpatients. The thermodynamic parameters of the antibodies were determined in 5 patients withpositive serum findings.Conclusion: With regard to the existence of heterogenious clinical findings in large amount ofpatients with antibodies against Staphylococcal enterotoxins, the next study of Staphylococcalenterotoxins role in pathogenesis of wide spectrum of diseases is necessary.

Key words:
toxic shock syndrome, Staphylococcal enterotoxins, gyneacological inflammations