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Efficacy and Safety of Fenfluramine in the Treatment of Lennox-Gastaut Syndrome –⁠ An Overview of Current Knowledge

21. 6. 2024 Source: Rare Diseases in Neurology

In a recently published article, British authors summarize the current knowledge on the efficacy and safety of fenfluramine (FFA) in the treatment of Lennox-Gastaut syndrome (LGS, a developmental and epileptic encephalopathy). In addition to the reduction in seizure frequency demonstrated in clinical studies, they discuss the impact of fenfluramine on reducing the risk of sudden unexpected death in epilepsy (SUDEP), improving cognitive function in patients, and its safety concerning weight loss and heart disorders.

Spectrum of Mechanisms of Action of Fenfluramine in the Treatment of Rare Epilepsies

Fenfluramine (FFA) is an anticonvulsant used in the treatment of rare epilepsies such as Dravet syndrome and Lennox-Gastaut syndrome. In addition to effectively reducing seizure frequency, it also…

21. 6. 2024 Source: Rare Diseases in Neurology

Hybrid Cooperating Complexes in Osteoarthritis Treatment

Intra-articular application of corticosteroids and hyaluronic acid is part of the treatment of osteoarthritis (OA) in patients for whom oral or topical treatment does not provide sufficient response.…

21. 6. 2024 Source: Pain Management

Possibilities of Cannabis Use in Tourette Syndrome Therapy

A retrospective analysis and online survey conducted at a psychiatric clinic in Hanover, Germany, investigated the effectiveness and safety of using cannabis products in patients with Tourette…

20. 6. 2024 Source: Medical Cannabis

Bimekizumab in the Treatment of Psoriatic Arthritis

Arthritis can appear in up to a third of patients with psoriasis, mostly after the onset of skin symptoms. Early recognition of this transition by dermatologists and general practitioners is crucial,…

20. 6. 2024 Source: Rheumatic Diseases

With Dr. Miroslav Nečas, Ph.D., on the conclusions of the recent consensus of the expert panel on the practice of biological treatment of psoriasis

This February, an expert consensus on the use of bimekizumab in the treatment of psoriasis and psoriatic arthritis (PsA) was published based on a literature review of 102 articles, from which 19…

19. 6. 2024 Source: Rheumatic Diseases

Interactive Case Study: Use of Cannabis Extract for Local Treatment of Neuropathic Pain

We have been using cannabis for pain treatment for several years. We also have good experiences with it in difficult-to-control symptoms of neuropathic pain, as illustrated in the following case…

19. 6. 2024 Source: Medical Cannabis

OHD 2024: What’s New in Data and Experiences from Real Practice with Venetoclax Regimens?

How to utilize venetoclax regimens most effectively for treating chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) in real practice was the topic of a satellite symposium organized…

19. 6. 2024 Source: Chronic Lymphocytic Leukemia

CASE STUDY: Rocker who can enjoy life again thanks to DM2 compensation p.o. semaglutide and better lifestyle

Diabetologist MUDr. Lucie Radovnická from Masaryk Hospital in Ústí nad Labem illustrates the case of her patient −⁠ a sympathetic rocker who enjoys life including concerts, beer, and good food −…

18. 6. 2024 Source: Modern Treatment of Diabetes with GLP-1 Analogues

Hybrid Cooperative Complexes in the Treatment of Osteoarthritis

18. 6. 2024 Source: Pain Management

Patient Journey Through the Danish Healthcare System with the Help of Digital Technologies –⁠ An Illustrative Case Study

The innovation and high degree of digitalization in Danish healthcare are well known around the world. The digitized system collects patient data, which is accessible to healthcare professionals…

18. 6. 2024 Source: proLékaře.cz

Off-label use of eye drops containing bromfenac in the treatment of cystoid macular edema in the only seeing eye of a complex patient –⁠ case report

The following case report discusses the effect of repeated use of an ophthalmic preparation containing bromfenac in a patient with recurrent cystoid macular edema (CME) in the only seeing eye with advanced...

14. 6. 2024 Source: Treatment of Glaucoma

Impact of a Deep Learning Model Predicting Sepsis on Quality of Care and Survival

Early recognition of sepsis is crucial for better patient prognosis. The following study presents the positive impact of applying a deep learning model for early prediction of sepsis on the health…

13. 6. 2024 Source: proLékaře.cz

Somapacitan administered once weekly in the treatment of children with growth hormone deficiency –⁠ current understanding

Somapacitan is a long-acting derivative of recombinant human growth hormone approved for the treatment of children and adults with growth hormone (GH) deficiency. Dr. Reiko Horikawa from Japan's…

12. 6. 2024 Source: Growth Disorders

CASE STUDY: Oral Semaglutide in a Young Diabetic = Weight Loss and CV Risk Reduction, Better Adherence and Treatment Comfort

Diabetologist MUDr. Tomáš Pfohl from the Regional Hospital Liberec illustrates the benefits of therapy with oral semaglutide in a relatively young diabetic patient with type 2 DM after unsatisfactory…

10. 6. 2024 Source: Modern Treatment of Diabetes with GLP-1 Analogues

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