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News Safety and Effectiveness of Lurasidone in Adolescents with Schizophrenia

An open-label extension of a placebo-controlled study involving 271 patients aged 13–17 years with schizophrenia showed minimal impact on body weight, lipid levels, prolactin, and blood glucose during 2 years of treatment while maintaining and deepening the alleviation of schizophrenia symptoms.

Source: Modern Treatment of Schizophrenia 18. 5. 2021

News Targeted Therapy for DLBCL Patients Who Cannot Undergo Bone Marrow Transplant

An international team of hemato-oncologists has been involved in testing polatuzumab vedotin in patients with diffuse large B-cell lymphoma (DLBCL) who have an unfavorable prognosis. In an article published at the beginning of 2020 in the Journal of Clinical Oncology, they analyze data collected in the early phases of clinical evaluation.

Source: Non-Hodgkin Lymphomas and CLL 11. 5. 2020

News The Importance of Early Diagnosis and Treatment of AATD in Preventing Pulmonary Emphysema

Alpha-1 antitrypsin deficiency (AATD) is a risk factor for the development of various diseases, including pulmonary emphysema. Currently, it is significantly underdiagnosed, and the availability of effective treatment is a reason for conducting its screening. The Czech Pneumological and Phthisiological Society ČLS JEP (ČPFS) recommends examining AAT levels in all patients with irreversible obstructive ventilatory disorders of any origin, direct relatives of patients with AATD, and individuals with chronic liver disease of unclear origin. The RAPID-OLE study has shown that treatment of alpha-1 antitrypsin deficiency modifies the course of this disease and underscores the importance of early intervention.

Source: Deficiency of Alpha-1-Antitrypsin 13. 7. 2020

News Experience from Clinical Practice with Intestinal Gel LECIG in Treating Parkinson's Disease

A Swedish observational study evaluated the applicability of the LECIG intestinal gel, which contains levodopa (20 mg/ml), carbidopa (5 mg/ml), and entacapone (20 mg/ml), in clinical practice for patients with Parkinson's disease.

Source: Parkinson's Disease 12. 5. 2022

Články časopisu Dysplasia and cervical cancer: current diagnostic possibilities

Author of the article: L. Rotter, P. Rotterová, I. Kinkorová Luňáčková, J. Kašpírková, M. Michal, R. Hudeček Source: Česká gynekologie | 4/2014 1. 8. 2014

Články časopisu Iron metabolism and its regulations

Author of the article: D. Vyoral, J. Petrák Source: Vnitřní lékařství | Suppl 2/2012 17. 8. 2012

News Biosimilar Bevacizumab in Patients with Non-Small Cell Lung Cancer

Biosimilar drugs are essentially analogous to generics for biological medicines. The patent protection for the original bevacizumab product will expire in the European Union in 2022. Consequently, several companies have already embarked on developing a biosimilar molecule.

Source: Oncological Treatment 15. 9. 2021

Články časopisu Hodgkin´s Lymhoma –⁠ the Treatment Aproaches Development and Current Trends

Author of the article: J. Kořen, M. Trněný Source: Klinická onkologie | Supplementum 3/2015 19. 10. 2015

News Current Treatment Options for Refractory/Relapsed CLL

How have treatment protocols for chronic lymphocytic leukemia changed in recent years? A review published in Acta Haematologica discusses the current therapeutic options for relapsed or refractory disease.

Source: Chronic Lymphocytic Leukemia 8. 9. 2022

News Results of Levothyroxine Treatment in Pregnant Women with Recurrent Pregnancy Losses with Subclinical Hypothyroidism or Anti-TPO Antibody Positivity

A recent meta-analysis of 15 studies involving a total of 1911 women with a history of recurrent pregnancy losses and positivity for thyroid peroxidase antibodies (TPOAb) or subclinical hypothyroidism showed the benefits of administering levothyroxine on pregnancy outcomes. Women with TPOAb experienced reductions in preterm births, miscarriages, premature rupture of membranes, and fetal growth retardation. Women with subclinical hypothyroidism saw an increase in live births and a decrease in miscarriages.

Source: Thyroid Disorders 16. 10. 2023

News Increase in Thyroid Cancer Incidence Due to the Coronavirus Pandemic?

According to available data, COVID-19 disease does not worsen the course of thyroid cancer. However, the restriction of medical care during the pandemic is associated with concern about an increase in the incidence of this malignant disease and the associated morbidity and mortality.

Source: Thyroid Disorders 6. 5. 2021

News To Vaccinate or Not to Vaccinate? That’s the Question for MS and COVID-19

What is the response of patients with multiple sclerosis (MS) to vaccination against COVID-19 considering the type of their treatment? Is there an increased risk of relapse after vaccination? And how to proceed with a particular patient? Although COVID-19 has been a relevant issue for a relatively long time, unfortunately, this topic remains current. Unlike in 2020, however, our knowledge has significantly advanced. Currently, relatively extensive data are available even for specific groups of the population –⁠ including precisely MS patients.

Source: Multiple Sclerosis 10. 10. 2022

News Effectiveness and Safety of Initiating Treatment for Primary Immunodeficiency with Subcutaneously Administered Immunoglobulins –⁠ A Systematic Review of the Literature

The aim of the systematic review of the literature published last year was to evaluate the effectiveness and safety of initiating treatment with subcutaneously administered immunoglobulins (SCIG) in patients with primary immunodeficiency (PID) who had not previously been treated with this modality. There was insufficient data available for such a defined population because SCIGs had typically been introduced into studies only after intravenously administered immunoglobulins (IVIG).

Source: Primary and Secondary Immunodeficiencies 1. 12. 2023

News The Role of Inflammation in the Cardiovascular Continuum and the Aging Process

Inflammation plays a role at various stages of the cardiovascular (CV) continuum, in both atherosclerotic and non-atherosclerotic CV diseases. Where to look for inflammation in the pathophysiology of CV diseases, why inflammation is related to aging, and how to utilize these findings in clinical practice was explained in a lecture by MUDr. Peter Wohlfahrt, Ph.D., from the Center of Preventive Cardiology IKEM in Prague, at the XXXII Annual Meeting of the Czech Cardiology Society.

Source: Risk factors of cardiovascular diseases 9. 7. 2024

News Sonicare Technology as a Modern Means for Good Oral Hygiene

Sonicare technology was developed and introduced to the market by Philips 30 years ago. Since then, the range of products has expanded, and the use of sonic technology has become accessible to a wide spectrum of patients with various problems and needs.

Source: Dental Care 23. 2. 2023