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News AAD 2023: Efficacy of Bimekizumab in the Treatment of Hidradenitis Suppurativa
At the latest annual congress of the American Academy of Dermatology (AAD), held March 17-22, 2023 in New Orleans, the results of the phase III BE HEARD I and II studies were presented among late-breaking presentations. The studies demonstrate the safety and high efficacy of bimekizumab in the treatment of adults with moderate to severe hidradenitis suppurativa (HS).
News DPP4 Inhibitors in Chronic Kidney Disease and Their Potential to Protect Against Diabetic Nephropathy
Preclinical and clinical observations suggest that dipeptidyl peptidase 4 (DPP4) inhibitors might offer additional benefits to patients apart from effective and safe glycemic control.
News 48 Tablets of Teriflunomide? Nothing Should Be Overdone! − Case Study
A case study published in the Journal of Clinical Pharmacy and Therapeutics describes an overdose of teriflunomide, specifically the ingestion of 672 mg of this drug. What measures did the doctors take with the patient? And were they able to prevent serious consequences?
News Electronic Cigarettes as an Alternative Option for Quitting Smoking?
Diseases caused by smoking tobacco products are a significant cause of global morbidity and mortality. One of the options for quitting smoking is electronic cigarettes, which, although not entirely researched yet, according to available studies, genuinely help people quit smoking and are associated with significantly lower health risks compared to traditional tobacco products.
News Transfer of Microbiome from Mother to Child: A Key but Fragile Process
How does the transfer of gut microbiota between mother and child occur? Is this transfer clinically significant, and what factors can disrupt it? These questions are addressed in a 2019 review article by Dutch microbiologists.
News CASE STUDY: Surgical Procedure in an Adolescent Patient with Severe Hemophilia A on Emicizumab Prophylaxis
This case study is narrated by MUDr. Bohumír Blažek from the Clinic of Pediatric Medicine at LF OU and FN Ostrava. The patient is a 17-year-old boy with severe hemophilia A. Several months prior to the procedure under discussion, he was switched from prophylactic factor VIII administration to emicizumab prophylaxis. Subsequently, an extraction of all four molars was planned for orthodontic reasons. The case study describes the hematologist's approach to the procedure and the subsequent healing process.
News Anticoagulation Therapy in Patients on ECMO During the COVID-19 Pandemic
In the past 2 years, the use of extracorporeal membrane oxygenation (ECMO) in intensive care units (ICU) has increased in connection with the treatment of severe COVID-19 pneumonia. Dr. Pilar Marcos Neira from the ICU at Germans Trias i Pujol Hospital in Barcelona has compiled a summary of updated knowledge on anticoagulation therapy in these patients.
News Adequate Anti-Xa Levels Are More Often Achieved in Trauma Patients When Dosing Enoxaparin Based on Weight
Thromboembolic disease (TED) is a well-known preventable cause of morbidity and mortality in trauma patients. To improve their prognosis, pharmacological thromboprophylaxis, such as with low molecular weight heparins (LMWH), is an essential part of treatment. However, previously published studies have pointed out that standard dosing of LMWH may be associated with insufficient levels of activity measured using the anti-Xa parameter.
News Targeted Therapy for DLBCL Patients Who Cannot Undergo Bone Marrow Transplant
An international team of hemato-oncologists has been involved in testing polatuzumab vedotin in patients with diffuse large B-cell lymphoma (DLBCL) who have an unfavorable prognosis. In an article published at the beginning of 2020 in the Journal of Clinical Oncology, they analyze data collected in the early phases of clinical evaluation.
News Does olaparib improve overall survival in patients with recurrent ovarian cancer and BRCA mutation?
Olaparib, a poly(ADP-ribose) polymerase (PARP) enzyme inhibitor, in tablet form is indicated, among other things, for the maintenance treatment of adult patients with platinum-sensitive recurrent high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer who respond (complete or partial response) to platinum-based chemotherapy. Its efficacy in this indication in terms of prolonging progression-free survival and overall survival was addressed by the phase III study presented below.
News Why Are Mucolytics Beneficial for Patients with COPD?
Part of the clinical picture of chronic obstructive pulmonary disease (COPD) includes mucus hypersecretion in the airways and its impaired clearance, resulting in a chronic productive cough. Mucus production requires management, just like dyspnea and cough. But what can be expected from mucolytic treatment?
News Current Trends in Proton RT of Head and Neck Tumors: Aiming to Preserve T Lymphocytes, Without Them, Treatment is Ineffective
Tumors of the head and neck are often diagnosed at an advanced stage. With the availability of modern treatments, such as immunotherapy or radiotherapy modalities, prognosis and chances for long-term survival are improving. We discuss trends not only in proton therapy for oropharyngeal tumors and the prospects of combining treatment methods for these diagnoses with the head doctor of the Proton Center Prague Associate Professor MUDr. Jiří Kubeš, Ph.D.
News Focused on MS: Statistics Are Boring, But They Have Valuable Data!
What is the prevalence of multiple sclerosis? Has the proportion of patients treated with highly effective therapy changed? We bring you the latest data from around the world and domestically.
News Severe Polytrauma in a Man with von Willebrand Disease − Case Report
The authors of a recently published case report present a case of multiple trauma (including brain injury) in a young man with von Willebrand disease (vWD) type 2A, in whom repeated administration of a concentrate containing von Willebrand factor (vWF) and coagulation factor VIII (FVIII) led to successful healing without neurological deficit.
News Incidence of Brain Metastases and Intracranial Activity of Sotorasib in Patients with NSCLC with G12C Mutation of the KRAS Oncogene
Sotorasib is the first targeted drug approved for the treatment of metastatic non-small cell lung cancer (NSCLC) with the G12C mutation of the KRAS oncogene. The newly published study presented below investigated its intracranial activity.
News Current findings on the treatment of gestational diabetes and DM2 in pregnancy with metformin
Recent reviews have shown that metformin is a safe alternative to insulin in the treatment of diabetes during pregnancy. For gestational diabetes (GDM) and type 2 diabetes mellitus (DM2), metformin administered to pregnant women has its benefits, but also certain risks.
News EMA Approved Empagliflozin for the Treatment of Heart Failure Regardless of Left Ventricular Ejection Fraction
Prague, March 8, 2022 – Hundreds of thousands of patients in the Czech Republic can soon look forward to a treatment that may positively influence the progression of their disease. The European Medicines Agency (EMA) approved the registration of Jardiance® (empagliflozin) for the treatment of adults with symptomatic chronic heart failure with preserved left ventricular ejection fraction at the beginning of March. It thus becomes the first drug that doctors can prescribe to all patients, regardless of ejection fraction status. EMA had previously approved empagliflozin for the treatment of patients with chronic heart failure with reduced ejection fraction and for the treatment of adults with inadequately controlled type 2 diabetes. The drug was developed by Boehringer Ingelheim.
News Physical Activity in Young Men with Hemophilia A
What may influence the inclusion of physical activity in the lifestyle of individuals with hemophilia? This was the focus of a Norwegian study published in the journal Haemophilia.
News New Treatment Options for Hemophilia Come with Discussions on Important Issues
The organizing committee of this year's virtual congress of the European Association for Haemophilia and Allied Disorders (EAHAD 2021) promised in the opening speech a "showcase of the latest innovations and advances in the field of hemophilia and bleeding disorders." The program naturally included discussions on current research findings and practical experiences. Topics included the potential role of coagulation factor VIII even with non-factor therapies and the importance of monitoring the success of new therapeutic approaches.
News Safety of Urgent Initiation of Peritoneal Dialysis
In case of urgent need for kidney function replacement, hemodialysis (HD) with a temporary venous catheter has long been the standard solution. However, it has several disadvantages such as increased mortality or the risk of bacteremia and central venous stenosis. Additionally, multiple procedures are needed to create a permanent venous access. Therefore, there is a growing global interest in urgently initiated peritoneal dialysis (PD), with several clinical studies attesting to its safety, efficacy, and feasibility. However, little has been known about early PD complications and the long-term prognosis of patients in terms of technical and infectious complications.
News Effect of Luspatercept Treatment in Patients with MDS/MPN-RS-T
The presented post hoc analysis of the MEDALIST study demonstrates the effect and good tolerance of luspatercept in the rare disease from the myelodysplasia group − MDS/MPN-RS-T.
News Dyslipidemia in the General Practitioner's Office – Featuring LDL Cholesterol
Monitoring LDL cholesterol (LDL-c) levels is crucial in diagnosing hypercholesterolemia as it is directly linked to increased cardiovascular risk. What other tests should be performed upon detecting hypercholesterolemia and which medications can effectively help reduce LDL-c levels?
News Cardio-renal-metabolic syndrome in context
The increase in the incidence of type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), and chronic kidney disease (CKD) ranks among the most significant health issues of our time. Based on recent studies, these conditions are likely interconnected at various levels, whether in epidemiology, pathophysiology, or patient prognosis. Consequently, the term cardio-renal-metabolic syndrome (CRMS) has been defined.
News Effect of Nuclear Magnetic Resonance Therapy in Patients with Osteoarthritis
Osteoarthritis represents the most common joint disease in adults, with its incidence and prevalence increasing with age. With the overall aging of the population, it is becoming a significant medical as well as social problem. Due to the growing number of cases, new modalities are being sought for current therapeutic procedures, including nuclear magnetic resonance therapy, whose effect has been verified by an extensive clinical study.
News Care for Dental Prostheses: What Did Clinical Study Results Reveal?
Dental prostheses are one of the most common solutions for missing teeth, especially in the elderly population. It is estimated that by 2050 up to 2 billion people will be aged 60 or older. Currently, it's not even half that, so it's likely that the number of people with dental prostheses will continue to increase. What do current research findings on dental prosthesis care reveal, and which cleaning methods have been evaluated as truly effective?