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News Artificial Intelligence Helps in Selecting Influenza Strains for Vaccine Production

Vaccination is one of the most important and effective preventive measures in the fight against seasonal epidemics caused by influenza viruses each year. For vaccines to work, they must match the currently circulating influenza strains. The timely selection of appropriate influenza strains, which will be the most widespread in the population in the upcoming period, and their yield are crucial for vaccine development. The new MAIVeSS (Machine-learning Assisted Influenza Vaccine Strain Selection) method, which uses artificial intelligence and machine learning algorithms for direct analysis of clinical samples, could help with this process.

Source: 17. 4. 2024

News Overall Survival in Patients with Metastatic CRC During 1st-Line Anti-EGFR Treatment Depending on the Presence or Absence of Hypomagnesemia

Hypomagnesemia is one of the side effects of monoclonal antibody therapy against the epidermal growth factor receptor (EGFR). The study presented below examined overall survival in patients with metastatic primarily unresectable colorectal cancer (CRC) treated with anti-EGFR therapy depending on the presence or absence of hypomagnesemia.

Source: Colorectal Cancer 3. 10. 2022

News Extract from Aloe barbadensis in the Treatment of Irritable Bowel Syndrome

The authors of a pooled analysis of two randomized controlled trials evaluated whether administration of Aloe barbadensis extract in patients with diarrhea-predominant irritable bowel syndrome (IBS) resulted in a significant reduction in the overall severity of symptoms.

Source: Irritable Bowel Syndrome 29. 4. 2022

News How do body weight and metabolic parameters change in patients first hospitalized for psychosis?

The most common cause of death in patients with schizophrenia is cardiovascular disease, which is closely related to obesity or metabolic syndrome. The study presented below examined changes in body weight and metabolic parameters during the first hospitalization of these patients.

Source: Modern Treatment of Schizophrenia 24. 11. 2023

News Is Obesity a Universal Phenotype in Children with Type 2 Diabetes?

What is the global prevalence of obesity in children and adolescents suffering from type 2 diabetes mellitus (T2DM)? Does the occurrence of obesity in pediatric T2DM correlate with gender or race? And how is obesity in T2DM under 18 years of age associated with glycemic control and dyslipidemia? These questions have been addressed by Canadian authors in their recently published systematic review and meta-analysis, which deals with various issues related to childhood obesity.

Source: Modern Treatment of Diabetes 19. 4. 2023

News Comparison of BEAM and TEAM Conditioning Regimens Before Autologous Hematopoietic Stem Cell Transplantation in the Treatment of Lymphomas

At the beginning of this year, one of the few studies comparing the most commonly used conditioning regimen before autologous hematopoietic stem cell transplantation (ASCT) in patients with lymphomas (BEAM) with a regimen containing thiotepa instead of carmustine (TEAM) was published.

Source: Oncological Treatment 13. 6. 2023

News Idiopathic Pulmonary Fibrosis: What Can a General Practitioner Do?

When a previously healthy patient becomes breathless, it's never good news. Among the particularly serious issues that breathlessness can signal is idiopathic pulmonary fibrosis (IPF). However, its prognosis no longer has to be as unfavorable as before, especially if diagnosed early.

Source: Pulmonary Fibrosis 19. 11. 2020

Články časopisu Significance of vitamin D for human health

Author of the article: S. Skácelová Source: Česká revmatologie | 1/2010 14. 4. 2010

News Self-administration of alpha-1-antitrypsin can significantly improve patients' quality of life

Treatment of alpha-1 antitrypsin deficiency (AATD) requires lifetime administration of weekly intravenous infusions of this substance, mostly in medical facilities. The possibility of AAT application at home is being discussed. This topic was also addressed at a symposium held during the European Respiratory Society (ERS) congress, which took place in November 2019 in Madrid.

Source: Deficiency of Alpha-1-Antitrypsin 20. 8. 2020

News Obeticholic Acid in the Treatment of Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid in Real Practice

An interim analysis of the OCARELIFE observational study presented at the European Association for the Study of the Liver (EASL) congress in August 2020 attempted to evaluate whether the safety and efficacy of obeticholic acid treatment in patients with primary biliary cholangitis (PBC) under real-life conditions after 12 months correspond to the results of clinical trials.

Source: Primary Biliary Cholangitis 14. 10. 2020

News Efficacy of Bisoprolol in Patients After Acute MI with LV Systolic Dysfunction

What impact does one year of bisoprolol use have in real-world practice on heart rate, left ventricular ejection fraction (LVEF), glycated hemoglobin (HbA1c) levels, or lipid profile in patients after acute myocardial infarction (AMI) with left ventricular systolic dysfunction (LVSD)? This was investigated by the authors of a study whose results were published last year.

Source: Cardiovascular Continuum 27. 3. 2023

News Cardiovascular Interventions with Continued Therapy with Dabigatran −⁠ Insights from the GLORIA-AF Study

An analysis using data from an international registry of patients with newly diagnosed atrial fibrillation evaluated the safety and efficacy of continued therapy with dabigatran during cardioversion or atrial fibrillation ablation, pacemaker implantation, and coronary angiography with possible stent implantation.

Source: Anticoagulant Treatment 12. 1. 2023

News Medium to Long-term Results of PFC Sigma Total Knee Arthroplasty

The PFC Sigma knee implant was introduced in 1997. It is the most commonly used system for total knee arthroplasty in England and Wales, accounting for 34.9% of primary implantations in 2006. Studies evaluating medium to long-term implantation outcomes have shown that it is an implant with a high survival rate, low re-implantation rate, and very good clinical results.

Source: Large Joints 23. 11. 2020

News Should We Test for Alpha-1-Antitrypsin in All COPD Patients?

Approximately 1–2% of patients with chronic obstructive pulmonary disease (COPD) have an alpha-1-antitrypsin (AAT) deficiency. This is an underdiagnosed genetic disorder that leads to rapid progression of COPD, although it is initially amenable to therapeutic intervention. Therefore, it is necessary to improve early detection of affected individuals. General practitioners can play a crucial role in this process.

Source: Deficiency of Alpha-1-Antitrypsin 10. 2. 2020

Články časopisu Bone manifestations of thyroid disorders

Author of the article: Bakos Bence, Takács István, Stern H. Paula, Lakatos Péter Source: Clinical Osteology | 3/2018 14. 5. 2019