Role of incretins in energy metabolism and weight changes after smoking cessation
Authors:
MUDr. Alexandra Pánková
Authors‘ workplace:
Ústav hygieny a epidemiologie 1. LF UK a VFN v Praze
; Centrum pro závislé na tabáku 3. interní kliniky 1. LF UK a VFN v Praze
Published in:
Čas. Lék. čes. 2016; 155: 151-153
Category:
Review Article
Overview
Incretine-based therapies are frequently used to treat patients with type 2 diabetes. Some of these drugs are used to induce weight loss. Liraglutide, a glucagon-like peptide 1 receptor agonist, was recently approved for the treatment of obesity. Smoking cessation is associated with weight gain. The mechanism responsible for the increase in body weight post cessation remains unclear. While increased caloric intake may play a role, weight gain may also be linked to nicotine, which has been shown to stimulate smokers’ basal metabolic rate. The effect of incretines on body weight and energy metabolism after smoking cessation is unclear. Recently published data suggests that incretine hormones may not be involved in the above mentioned changes.
Keywords:
smoking cessation , body weight, glucagon-like peptide 1, glucose-dependent insulinotropic peptide, leptin
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