From the adult type through NIDDM and second type of diabetes – what is coming thereafter?

Czech version

Authors: Oliver Rácz ^1,2; Eva Sedláková ¹
Authors‘ workplace: Ústav patologickej fyziológie LF UPJŠ v Košiciach ¹; Miskolci Egyetem – Egészségtudományi Kar, Maďarsko ²
Published in: Diab Obez 2022; 22(43): 16-19
Category: Reviews

Overview

Critical analysis of the proposal of new diabetes mellitus subtypes. In the proposal the current type 1 diabetes (together with the late autoimmune diabetes) is renamed to Severe AutoImmune Diabetes (SAID) and the current type 2 is divided into four subtypes: Severe Insulin Deficient Diabetes, Severe Insulin Resistant Diabetes, Mild Obesity- related Diabetes and Mild Age-Related Diabetes (SIDD, SIRD, MOD, MARD). From point of view of pathological physiology the new proposal is a significant step towards the classification of different forms of the disease taking into account the complex and heterogenous pathogenesis of diabetes mellitus. Application of new subtypes in everyday diabetology practice should be an important contribution to precision and personalized medicine.

Keywords:

Cluster analysis – insulin resistance – diabetes mellitus – mendelian randomization – insulin deficiency – subtypes of diabetes mellitus

Sources

1. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20(7): 1183–1197. Dostupné z DOI: <http://dx.doi.org/10.2337/diacare.20.7.1183>.

2. Del Prato S, Bianchi C, Daniele G. Abnormalities of insulin secretion and β-Cell defects in Type 2 diabetes In: Holt RIG et al (eds). Textbook of diabetes. 5th ed. Wiley Blackwell: 2015: 161–173. ISBN 978–111–891–2027.

3. Hauner H. Obesity and diabetes. In: Holt RIG et al (eds) 5th ed. Textbook of diabetes. Wiley Blackwell: 2015: 215–228. ISBN 978–111–891–2027.

4. De Fronzo RA. Pathogenesis of type 2 diabetes mellitus. In: De-Fronzo RA et al (eds). International textbook of diabetes. 4th ed. Wiley Blackwell: 2015: 371–400. ISBN 978–0-470–65861–1.

5. Alonge KM, D’Alessio DA, Schwartz MW. Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes. Diabetologia 2021; 64(1): 5–14. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–020–05293–3>.

6. Franks PW, Pomares-Millan H. Next-generation epidemiology: the role of high-resolution molecular phenotyping in diabetes research. Diabetologia 2020; 63(12): 2521–2532. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–020–05246-w>.

7. Zhang Y, Pan XF, Chen J et al. Combined lifestyle factors and risk of incident type 2 diabetes and prognosis among individuals with type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Diabetologia 2020; 63(1): 21–23. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–019–04985–9>.

8. Barres R, Zierath JR. The role of diet and exercise in the transgenerational epigenetic landscape of T2DM. Nature Rev Endocrin 2016; 12(18): 441–451. Dostupné z DOI: <http://dx.doi.org/10.1038/nrendo.2016.87>.

9. Winkler G. Az inzulinrezisztencia valós és téves értelmezése a klinikai gyakorlatban. (Správna a nesprávna interpretácia inzulínovej rezistencie v klinickej praxi). Orv Hetil 2020; 161(26): 1088–1093. Dostupné z DOI: <http://dx.doi.org/10.1556/650.2020.31760>.

10. Sotak S. Diabetes mellitus 1. typu – „Mizerná jedenástka“. Interná Med 2020; 20(4): 171–174.

11. Yuan S, Larsson S. An atlas of risk factors for type 2 diabetes: a wide-angled Mendelian randomization study. Diabetologia 2020; 63(11): 2359–2371. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–020–05253-x>.

12. Ahlquist E, Storm P, Käräjämäki A et al. Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables. Lancet Diabetes Endocrinol 2018; 6(5): 361–369. Dostupné z DOI: <http://dx.doi.org/10.1016/S2213–8587(18)30051–2>.

13. Ahlqvist E, Prasad RM, Groop L. Subtypes of type 2 diabetes determined from clinical parameters. Diabetes 2020; 69(10): 2086–2093. Dostupné z DOI: <http://dx.doi.org/10.2337/dbi20–0001>.

14. Ahlqvist E, Prasad RB, Groop L. 100 YEARS OF INSULIN: Towards improved precision and a new classification of diabetes mellitus. J Endocrin 2021; 252(3): R59-R70. Dostupné z DOI: <http://dx.doi.org/10.1530/JOE-20–0596>.

15. Zhou X, Zhou X, Zhu Z et al. Novel subgroups of patient with adult-onset diabetes in Chinese and US populations. Lancet Diabetes Endocrinol 2019; 7(1): 9–11. Dostupné z DOI: <http://dx.doi.org/10.1016/S2213–8587(18)30316–4>.

16. Kahkoska AR, Geybels MS, Klein KR et al. Validation of distinct type 2 diabetes clusters and their association with diabetes complications in the DEVOTE, LEADER and SUSTAIN-6 cardiovascular outcomes trials. Diabetes Obes Metab 2020; 22(9): 1537–1547. Dostupné z DOI: <http://dx.doi.org/10.1111/dom.14063>.

17. Slieker RC, et al Replication and cross-validation of type 2 diabetes subtypes iabased on clinical study. Diabetologia 2019; 64: 1973–1981.

18. Slieker RC, Donnelly LA, Fitipaldi H et al. Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study. Diabetologia 2021; 64(9): 1982–1989. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–021–05490–8>.

19. Pigeyre M, Hess S, Gomez MF et al. Validation of the classification for type 2 diabetes into five subgroups: a report from the ORIGIN trial. Diabetologia 2022; 65(1): 206–215.Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–021–05567–4>.

20. McCarthy MI. Painting a new picture of personalised medicine for diabetes. Diabetologia 2017; 60(5): 793–799. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–017–4210-x>.

21. Herder C, Roden M. A novel diabetes typology: towards precision diabetology from pathogenesis to treatment. Diabetologia 2022. Dostupné z DOI: <http://dx.doi.org/10.1007/s00125–021–05625-x>.