Co-formulation of insulin degludec and insulin aspartate in realworld clinical practice: the ARISE study

Czech version

Authors: Zbynek Schroner ^1,2
Authors‘ workplace: Lekárska fakulta UPJŠ v Košiciach ¹; SchronerMED, s. r o., Košice ²
Published in: Diab Obez 2022; 22(43): 39-43
Category: Clinical studies

Overview

1^st Oct 2021 came to clinical practice in Slovak republic new co-formulation of insulin degludec and insulin aspart (IDegAsp). Clinical trial program with IDegAsp has the name BOOST. IDegAsp among all the trials proved good glycemic control, lower insulin dose and risk of hypoglycemia. Some studies from real clinical practice were done with IDegAsp. ARISE was a 26-week, multicenter, prospective, non-interventional study from a real clinical practice. The aim of the study was to investigate changes in relevant clinical parameters, such as glycemic control and rate of hypoglycemia in patients who initiated or switched insulin regime to treatment with IDegAsp. The primary endpoint was change in HbA_1c from baseline to end of study. Across all prior therapy subgroups, treatment with IDegAsp was associated with significant improvement in HbA_1c. Significant reductions of FPG, weight, rate of hypoglycemia and total and basal dose of insulin were also observed.

Keywords:

ARISE – studies from real clinical practice – study IdegAsp

Sources

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