Adipocytokines as possible etiopathogenetic mechanisms leading to a higher incidence of autoimmune thyroiditis in patients with type 2 diabetes mellitus – enlarged study

Czech version

Authors: Štefan Sotak ¹; Zbynek Schroner ^2,3; Ivica Lazúrová ¹; Ivana Jochmanová ¹; Marek Felš Ci ¹; Darina Petrášová ⁴; Izabela Bertková ⁵; Miriam Mitníková ⁶
Authors‘ workplace: I. interná klinika LF UPJŠ a UNLP Košice ¹; Lekárska fakulta UPJŠ v Košiciach ²; SchronerMED, s. r. o. Košice ³; Laboratórium výskumných biomodelov LF UPJŠ v Košiciach ⁴; Ústav experimentálnej medicíny LF UPJŠ v Košiciach ⁵; Oddelenie laboratórnej medicíny UNLP Košice ⁶
Published in: Diab Obez 2022; 22(43): 44-51
Category: Clinical studies

Overview

Introduction: Autoimmune thyroiditis (AIT) and type 2 diabetes mellitus (T2D) are the most common endocrinological diseases worldwide. Relationship between T1D and AIT is well-known and described. Relation between these diseases explains several hypotheses. One of them is influence of some adipocytokines. Objective: This study evaluated relationship between three adipocytokines (adiponectin, resistin, visfatin) and thyroidal status in patients with T2D and AIT compared to control group (CG). Material and methods: The group consisted of four subgroups: patients with T2D without thyreopathies (n = 80), patients with AIT on substitution therapy without diabetes and prediabetes (n = 54), patients with T2D and AIT on substitution therapy (n = 47) and healthy subjects as a CG (n = 43). We investigated parameters of thyroid and glycid metabolism and levels of three adipocytokines by venous blood-letting. We also measured thyroid gland volume, height, weight and waist. Results: The mean level of resistin in the group of patients with diabetes and thyroiditis was significantly higher than in patients with thyroiditis without diabetes and than in the CG. We found a weak negative correlation between visfatin and fasting glucose levels in patients with thyroiditis without diabetes. We detected a weak negative correlation between resistin and glycated hemoglobin and a weak negative correlation between visfatin and thyroid gland volume in patients with diabetes without thyroiditis. In the CG we determined a weak positive correlation between visfatin and free thyroxin. Conclusion: Our results are consistent with several studies, which confirmed association between AIT and adipocytokines. This is a continuation of the study with the same focus from 2019. The number of examined individuals increased to more than one and a half times.

Keywords:

Adiponectin – type 2 diabetes mellitus – adipocytokines – autoimmune thyroiditis – resistin – visfatin

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