Cardiovascular effect of GLP-1 receptor agonists: meta-analyses suggest a class effect

Czech version

Authors: Peter Novodvorský ^1,2,3
Authors‘ workplace: metabolické centrum s. r. o., Trenčín ¹; Centrum diabetologie IKEM, Praha ²; Department of Oncology and Metabolism, Medical School, University of Sheffield, United Kingdom ³
Published in: Diab Obez 2022; 22(43): 20-23
Category: Reviews

Overview

The position of GLP-1 receptor agonists (GLP-1 RA) in therapeutic guidelines for management of type 2 diabetes (T2DM) is constantly improving alongside the growing evidence for their pleiotropic effects including their glucose-lowering abilities with low risk of hypoglycaemia, reduction of body weight as well as positive effects on cardiovascular outcomes. At the same time, several clinically relevant questions emerge in relation to the generalisability of their benefits to distinct types of T2DM populations as well as to the differences in specific molecules of GLP-1 RA. In this paper, I discuss these issues in the light of the recently published large meta-analyses.

Keywords:

cardiovascular system – GLP1 receptor agonists – cardiovascular benefits – renal benefits

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