Comparison of cardiovascular studies with GLP-1 receptor agonists and their implication for clinical practice

Czech version

Authors: Zbynek Schroner
Authors‘ workplace: SchronerMED s. r. o., Košice
Published in: Diab Obez 2020; 20(39): 51-55
Category: Clinical studies

Overview

Väčšina diabetikov 2. typu je v pásme vysokého alebo veľmi vysokého kardiovaskulárneho (KV) rizika, aj keď ešte nemajú manifestné KV-ochorenie. V súčasnosti ešte prebiehajú, ale väčšinou už boli ukončené veľké klinické dlhodobé randomizované štúdie zamerané na vplyv agonistov GLP1 receptorových agonistov (GLP1 RA) na KV-morbiditu a mortalitu. Liečba GLP1 RA vykazuje viaceré multiorgánové benefity. V rámci individualizovaného prístupu liečba GLP1 RA by mala byť preferovaná už vo včasných štádiach diabetes mellitus 2. typu, so subklinickými prejavmi aterosklerózy, zatiaľ bez manifestného KV-ochorenia.

Keywords:

cardiovascular studies – GLP-1 receptors agonists – implications of studies – type 2 diabetes mellitus

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