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Findings in Cerebrospinal Fluid among Children with Paretic Involvements


Authors: L. Krbková 1;  K. Holečková 2;  Z. Blechová 3;  V. Marešová 3;  K. Labská 3;  H. Štroblová 4;  J. Bednářová 4
Authors‘ workplace: Klinika dětských infekčních nemocí LF MU a FN Brno 1;  Klinika infektológie a geografickej medicíny LF SZU, LF UK a UN Bratislava 2;  I. infekční klinika 2. LF UK a Nemocnice Na Bulovce, Praha 3;  Oddělení klinické mikrobiologie, FN Brno 4
Published in: Cesk Slov Neurol N 2014; 77/110(4): 496-500
Category: Short Communication

Overview

Aim:
To evaluate cerebrospinal fluid (CSF) findings in children with paretic involvements and to establish the benefit of such examination with a view to aetiological dia­gnosis.

Material and methods:
CSF findings among 227 hospitalized children with paretic involvements of the peripheral or central nervous system were evaluated retrospectively. CSF was analysed cytologically and bio­chemically. Detected were antibodies against neurotropic viruses, Borrelia and viral nucleic acids by means of PCR.

Results:
Inflammatory changes due to aseptic meningitis were found in 125 (55%) children, elevation of proteins only in nine (4%) children, and CSF examination was negative in the remaining 93 (41%) children. Cytological examination revealed white blood cells with a predominance of lymphocytes (mean 110, median 10). Median CSF protein was 0.4 g/ l and median CSF glucose was 3.34 mmol/ l. Disruption of the blood‑CSF barrier was determined in 55/ 113 (51%) children, while this condition was severe in 9% of the examined children. Borrelial aetiology was confirmed in 52% of the children, while pleocytosis was revealed in 86% of those samples. Viral and mycoplasmal aetiology was proven in 11% of the children only serologically. The aetiology remained unproven in 37% of the children.

Conclusion:
CSF examination contributed to the dia­gnosis of paretic involvements in children. Even despite negative meningeal signs in children, spinal tap should be performed to exclude or confirm meningitis. In our geographic conditions, peripheral facial palsy is dia­gnosed in 95% of children with the predominance of borrelial aetiology. Paretic involvements of other aetiologies occur only rarely.

Key words:
cerebrospinal fluid – pleocytosis – peripheral facial palsy – neuroborreliosis – herpes virus


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Labels
Paediatric neurology Neurosurgery Neurology

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Czech and Slovak Neurology and Neurosurgery

Issue 4

2014 Issue 4

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