The importance of adherence in tuberculosis treatment clinical trials and its relevance in explanatory and pragmatic trials

English version

Autoři: Andrew Vernon ^aff001; Katherine Fielding ^aff002; Rada Savic ^aff004; Lori Dodd ^aff005; Payam Nahid ^aff006
Působiště autorů: Clinical Research Branch, Division of TB Elimination, NCHHSTP, US Centers for Disease Control & Prevention, Atlanta, Georgia, United States of America ^aff001; TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom ^aff002; Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa ^aff003; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America ^aff004; National Institute for Allergy and Infectious Disease, National Institutes of Health, Washington DC, United States of America ^aff005; Division of Pulmonary and Critical Care Medicine, University of California, San Francisco at San Francisco General Hospital, San Francisco, California, United States of America ^aff006
Vyšlo v časopise: The importance of adherence in tuberculosis treatment clinical trials and its relevance in explanatory and pragmatic trials. PLoS Med 16(12): e32767. doi:10.1371/journal.pmed.1002884
Kategorie: Collection Review
doi: https://doi.org/10.1371/journal.pmed.1002884

Souhrn

Andrew Vernon and co-authors discuss adherence to therapy and its measurement in tuberculosis treatment trials.

Klíčová slova:

Clinical trials – Drug adherence – Drug metabolism – Drug screening – Ingestion – Pharmacokinetics – Tuberculosis – Urine

Zdroje

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