Estimated glomerular filtration rate and problems in the interpretation of CKD-EPI equations.
(Short communication - data expansion and comments to the article „Estimated glomerular filtration rate in diabetic patients“ published by Šálek, T. and Ponížil, P.)

Česká verze

Authors: A. Jabor ¹; J. Franeková ¹; Z. Kubíček ¹; T. Šálek ²
Authors place of work: Pracoviště laboratorních metod, IKEM Praha ¹; Oddělení klinické biochemie, Baťova nemocnice, Zlín ²
Published in the journal: Klin. Biochem. Metab., 22 (43), 2014, No. 1, p. 8-10

Summary

Authors followed the article „Estimated glomerular filtration rate in diabetic patients“ published by Šálek, T. and Ponížil, P. We expanded original data set (N=565) with additional 950 examinations and compared equations for glomerular filtration rate estimation (eGFR) from KDIGO 2012 Guidelines (equation CKD-EPI, version 2009 for creatinine only, version 2012 for cystatin C only and version 2012 for the combination of creatinine + cystatin C). Authors concluded, that CKD-EPI equations offer different results in different intervals of glomerular filtration. Cystatin C based equation (CKD-EPI 2012, cystatin C) offers higher values of eGFR in the interval above 1.5 ml/s per 1.73 m² in comparison to the equation CKD-EPI 2009 (creatinine) and vice versa in the interval below 1.5 ml/s per 1.73 m². Combined equation CKD-EPI 2012 (creatinine + cystatin C) is more related to the concentration of cystatin C than to the concentration of creatinine. These results may have impact on the interpretation and strategy of GFR estimation in clinical practice.

Keywords:
creatinine, cystatin C, glomerular filtration.

Zdroje

1. Šálek, T., Ponížil, P. Estimated glomerular filtration rate in diabetic patients. Klin. Biochem. Metab., 22 (43), 2014, No. 1, p. 4–7.

2. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney International Supplements, 2013, Vol. 3(1), p. 1–150

3. Saenger, A. K., Lockwood, C., Snozek, C. L. et al. Catecholamine Interference in Enzymatic Creatinine Assays. Clin. Chem., 2009, 55(9), p. 1732-1736.

4. Weber, J. A., van Zanten, A. P. Interferences in Current Methods for Measurements of Creatinine. Clin. Chem., 1991, 37(5), p. 695-700.