What we know and still do not know about tick-borne encephalitis?

Česká verze

Authors: M. F. Kříha ^1,2; A. Chrdle ^1,3,4; D. Růžek ^2,5,6; V. Chmelík ^1,2
Authors place of work: Infekční oddělení, Nemocnice České Budějovice, a. s., České Budějovice ¹; Katedra medicínské biologie, Přírodovědecká fakulta, Jihočeská univerzita v Českých Budějovicích, České Budějovice ²; Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Liverpool UK ³; Zdravotně sociální fakulta, Jihočeská univerzita v Českých Budějovicích, České Budějovice ⁴; Laboratoř arbovirologie, Parazitologický ústav, Biologické centrum Akademie věd České republiky, České Budějovice ⁵; Oddělení infekčních chorob a preventivní medicíny, Výzkumný ústav veterinárního lékařství v Brně, Brno ⁶
Published in the journal: Epidemiol. Mikrobiol. Imunol. 70, 2021, č. 3, s. 189-198
Category: Souhrnné sdělení

Summary

Tick-borne encephalitis (TBE) is a febrile illness caused by tick-borne encephalitis virus (TBEV), frequently manifesting as inflammation of the central nervous system. TBEV is a typical arbovirus, i.e., belongs to a group of viruses transmitted by blood-sucking arthropods. Taxonomically, TBEV is a member of the genus Flavivirus, family Flaviviridae. The disease is endemic in North Eurasia, from western Europe to East Asia. The virus occurs in natural foci of the disease all over Czechia, where it is transmitted predominantly by the castor bean tick (Ixodes ricinus). This infection has a potential to cause significant long-term disability affecting the quality of the patient’s life. Vaccine is available; however, vaccination coverage in Czechia is still low (around 30% of the total population). Lately, attention has been focused on new possibilities for early diagnosis and specific treatment, which so far has only been symptomatic or empirical.

Keywords:

Tick-borne encephalitis – tick-borne encephalitis virus – Pathogenesis – diagnostics – therapy – vaccination

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