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Vessel density and retinal nerve fiber layer in pathological intraocular pressure


Vessel density and retinal nerve fiber layer in pathological intraocular pressure

Aim: The aim of the study was to determine the correlation between intraocular pressure (IOP) and thickness of the retinal nerve fiber layer (RNFL), and vascular density (VD) in the optic nerve.

Material and methodology: IOP was greater than 21 mmHg (21–36 mmHg) in all eyes and was measured as the result of an average of three measurements with the instrument Ocular Response Analyzer (ORA, Reichert). RNFL and VD thickness (in the papillary region of 4.5 x 4.5 mm) was measured with the instrument Avanti RTVue XR (Optovue). In the case of the VD, the scan area was further separated into individual anatomical segments. In the case of corrected RNFL (RNFLc), the VD value was subtracted from the total RNFL value. The relationship of IOP to VD, RNFL and RNFLc in each peripapillary segment was determined using a Pearson’s correlation coefficient.

Results: The most significant correlation with IOP was observed for small vessel VD in a full scan (r = -0.48) and VD in the IT segment (r = -0.48). A similar correlation was observed for IOP and RNFL (r = -0.42). No statistically significant correlation was observed for RNFLc.

Conclusion: We demonstrated that VD values, specifically WI-VDs and peripapillary VDs in the IT segment, are significant markers for the early diagnosis of glaucoma.

Keywords:

intraocular pressure – vessel density – retinal nerve fiber layer


Autoři: Král Jakub;  Lešták Ján;  Fůs Martin
Působiště autorů: Kladno, Czech Republic ;  Faculty of Biomedical Engineering Czech Technical University in Prague
Vyšlo v časopise: Čes. a slov. Oftal., 81, 2025, No. Ahead of Print, p. 1-5
Kategorie: Původní práce
doi: https://doi.org/10.31348/2025/15

Souhrn

Aim: The aim of the study was to determine the correlation between intraocular pressure (IOP) and thickness of the retinal nerve fiber layer (RNFL), and vascular density (VD) in the optic nerve.

Material and methodology: IOP was greater than 21 mmHg (21–36 mmHg) in all eyes and was measured as the result of an average of three measurements with the instrument Ocular Response Analyzer (ORA, Reichert). RNFL and VD thickness (in the papillary region of 4.5 x 4.5 mm) was measured with the instrument Avanti RTVue XR (Optovue). In the case of the VD, the scan area was further separated into individual anatomical segments. In the case of corrected RNFL (RNFLc), the VD value was subtracted from the total RNFL value. The relationship of IOP to VD, RNFL and RNFLc in each peripapillary segment was determined using a Pearson’s correlation coefficient.

Results: The most significant correlation with IOP was observed for small vessel VD in a full scan (r = -0.48) and VD in the IT segment (r = -0.48). A similar correlation was observed for IOP and RNFL (r = -0.42). No statistically significant correlation was observed for RNFLc.

Conclusion: We demonstrated that VD values, specifically WI-VDs and peripapillary VDs in the IT segment, are significant markers for the early diagnosis of glaucoma.

Stránka

Štítky
Oftalmologie

Článek vyšel v časopise

Česká a slovenská oftalmologie

Číslo Ahead of Print

2025 Číslo Ahead of Print
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