Vliv přípravku «Saprogel» na process hojetí ran u potkanů s modelem rány v plné tloušťce

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Autoři: Oksana Strus ¹; Natalia Polovko ²
Působiště autorů: Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University ¹; Department of Drug Technology, National University of Pharmacy, Kharkiv, Ukraine ²
Vyšlo v časopise: Čes. slov. Farm., 2020; 69, 75-82
Kategorie: Původní článek

Souhrn

Článek představuje výsledky studie účinnosti a mechanismu účinku Saprogelu na proces hojení ran a pro/antioxidační rovnováhu v séru potkanů s modelem rány v plné tloušťce. Účinek hojení ran testovaných vzorků gelu byl hodnocen na základě dynamiky změny plochy (S) a procentního snížení plochy ran (PRA) ve 3., 7. a 14. dni léčby. Obsah produktů lipidové peroxidace (LPO) a aktivita antioxidačních ochranných enzymů v séru potkanů byla stanovena dynamicky v různých fázích procesu hojení ran u potkanů. Léčba ran rány s plnou tloušťkou u potkanů snížila dobu jejich hojení o 24,5 % (p < 0,05), ale nebyl zaznamenán statisticky významný rozdíl mezi účinkem přípravku «Saprogel» a srovnávacího produktu na dobu hojení ran. Obsah produktů LPO v séru pokanů byl při použití Saprogelu snížen a enzymatická aktivita antioxidační ochrany SOD a CAT byla normalizována, což naznačuje, že jedním z mechanismů hojení ran jsou jeho antioxidační vlastnosti.

Klíčová slova:

extrakt Sapropelu – dermatotropní gelový produkt – proces hojení ran – pro-/antioxidační rovnováha

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