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Genetic Testing in Clinical Practice –⁠ An Irreplaceable Tool in Prevention, Diagnosis and Treatment

4. 4. 2023 Source: Genetics

Genetic testing has long ceased to be the privilege of clinical research. In practice, it is commonly used for screening, diagnosis, and prognosis determination in diseases with an evident genetic component, and subsequently for tailoring pharmacotherapy to the individual patient. The richest experience with genetic testing belongs to reproductive medicine and the field of prenatal diagnostics, as well as pediatrics associated with rare disease medicine and oncology. Today, the significance of testing is becoming apparent in internal medicine and...

What Lies Behind ChatGPT? Artificial Intelligence with Potential Use Even in Clinical Medicine

ChatGPT, a program that enables conversation with sophisticated 'artificial intelligence', or rather an algorithm based on machine learning, is currently a huge hit. However, it represents just the…

4. 4. 2023 Source: proLékaře.cz

Subcutaneous Immunoglobulin Substitution in Ig-Naive Patients with PID –⁠ Available Efficacy and Safety Data

The prevalence of primary immunodeficiencies (PID) is estimated at 1 : 10,000. Below, we summarize the available findings on the efficacy and safety of subcutaneous immunoglobulin substitution in…

3. 4. 2023 Source: Primary and Secondary Immunodeficiencies

Bimekizumab in the Treatment of Psoriasis After Failure of (Not Only) Anti-IL-17A Antibodies –⁠ Case Reports

German authors last year described the first 2 cases of patients with psoriasis in whom treatment with, among other things, anti-IL-17A antibodies failed, but who responded to the blockade of…

2. 4. 2023 Source: Psoriasis

Metamizole in Pain Therapy in the General Practitioner and Pediatric Office

Metamizole is a pyrazole analgesic-antipyretic with spasmolytic effects, indicated for the treatment of post-traumatic or postoperative pain, visceral colic, cancer pain, and high fever unresponsive…

30. 3. 2023 Source: Updates in Pain Treatment

Non-Steroidal Anti-Inflammatory Drugs in the Treatment of Ankylosing Spondylitis: Network Meta-Analysis

A literature review and network meta-analysis of randomized controlled trials published in the journal Experimental and Therapeutic Medicine demonstrates the high efficacy and good tolerability of 6…

30. 3. 2023 Source: Updates in Pain Treatment

Metamizole as an Analgesic with a Favorable Benefit-Risk Ratio

Metamizole is a well-established and widely used molecule in many countries worldwide, suitable as an alternative to opioids for patients with moderate to severe acute or chronic pain. The popularity…

29. 3. 2023 Source: Analgesia

Doc. Jitka Fricová: The biggest challenge remains the patient with unbearable chronic pain

Research findings are pushing the boundaries of optimal chronic pain treatment, including better prevention and reduced side effects of analgesics. Algological care is readily accessible in the Czech…

29. 3. 2023 Source: Analgesia

The main advantage of sartans is a very good safety profile. Now it is about increasing adherence in hypertensive patients

The rules for initiating hypertension treatment have been simplified. The trend is to achieve blood pressure control as early as possible, making it unnecessary to wait for a longer period for the…

28. 3. 2023 Source: Sartans in the Treatment of Hypertension

Beta-blockers in the treatment of chronic heart failure: How did the analysis of the effects of 4 drugs in 26 studies turn out?

As a cornerstone of therapy for chronic heart failure with reduced ejection fraction (HFrEF), it is recommended to start treatment with a very low dose of beta-blockers (BB) and titrate it to the…

28. 3. 2023 Source: Cardiovascular Continuum

Efficacy of Bisoprolol in Patients After Acute MI with LV Systolic Dysfunction

What impact does one year of bisoprolol use have in real-world practice on heart rate, left ventricular ejection fraction (LVEF), glycated hemoglobin (HbA1c) levels, or lipid profile in patients…

27. 3. 2023 Source: Cardiovascular Continuum

INFOGRAPHIC: How does liposomal ozonized oil work in treating eye infections?

Ozonized sunflower oil exhibits antimicrobial, anti-inflammatory, and healing properties, which is why it is added to eye drops intended for infection prevention. We bring you a clear schematic of…

24. 3. 2023 Source: Treatment of Glaucoma

Liposomal Ozonated Oil in the Treatment of Eye Infections

Liposomal ozonated oil is a new ocular antiseptic with antibacterial, anti-inflammatory, and regenerative properties, making it suitable for the prevention and treatment of eye infections and as an…

24. 3. 2023 Source: Treatment of Glaucoma

H₂FPEF Score for Estimating the Probability of Heart Failure with Preserved Ejection Fraction in Persons with Unexplained Dyspnea

The simple, validated H₂FPEF scoring system based on clinical and echocardiographic parameters, developed by experts from the Mayo Clinic, allows the differentiation of heart failure with preserved ejection...

23. 3. 2023 Source: Heart Failure

“Smart” Bra as a Helper in Breast Cancer Detection

Malignant breast tumors represent one of the most common oncological diseases in women worldwide. For improving patient prognosis, it is crucial to detect the disease in its early, curable stages. In…

23. 3. 2023 Source: proLékaře.cz

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